Title
Nonhistone chromosomal protein synthesis: utilization of preexisting and newly transcribed messenger RNA's
UMMS Affiliation
Department of Cell Biology
Publication Date
1973-07-06
Document Type
Article
Subjects
Chromatin; Chromosomes; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Female; Hela Cells; Humans; Mitosis; Nucleoproteins; RNA, Messenger; Templates, Genetic; Transcription, Genetic; Tritium; Tryptophan
Disciplines
Cell Biology
Abstract
Treatment of HeLa S(3) cells with actinomycin D during mitosis suppresses the synthesis of several major classes of nonhistone chromosomal proteins during the subsequent period before DNA replication, but allows the synthesis of other species of these proteins. Such results are consistent with the utilization of preexisting, as well as newly transcribed, messenger RNA's for nonhistone chromosomal protein synthesis during the prereplicative phase of the cell cycle.
Source
Science. 1973 Jul 6;181(94):71-3.
Journal/Book/Conference Title
Science (New York, N.Y.)
Related Resources
PubMed ID
4714292
Repository Citation
Stein, Gary S. and Matthews, David E., "Nonhistone chromosomal protein synthesis: utilization of preexisting and newly transcribed messenger RNA's" (1973). Stein, Stein, Lian, vanWijnen Lab Publications. 224.
https://escholarship.umassmed.edu/stein/224