Title
Nonhistone chromosomal proteins and gene regulation
UMMS Affiliation
Department of Cell Biology
Publication Date
1974-03-01
Document Type
Article
Subjects
Animals; Chickens; Chromatin; *Chromosomes; DNA Replication; Electrophoresis, Polyacrylamide Gel; Female; *Genes, Regulator; Gonadal Steroid Hormones; Histones; Humans; Mice; Mitosis; Models, Biological; Nucleoproteins; Phosphoproteins; Progesterone; Protein Binding; Protein Biosynthesis; RNA; Rats; Receptors, Cell Surface; *Transcription, Genetic
Disciplines
Cell Biology
Abstract
Evidence from several model systems suggests that nonhistone chromosomal proteins may regulate gene expression in eukaryotic cells. The data indicate that the synthesis of new species of nonhistone chromosomal proteins as well as modifications of preexisting nonhistone chromosomal proteins are involved in the control of transcription. However, from the vast number of proteins included in this class, it is apparent that, in addition to regulating the transcription of defined genome loci, the nonhistone chromosomal proteins include enzymes that have a general function, proteins that are involved in determining the structure of chromatin, as well as proteins that serve as recognition sites for binding of regulatory macromolecules. The presence of a nucleoplasmic pool of nonhistone chromosomal proteins which may exchange with the chromatin has also been reported (89). While it is clear that the nonhistone chromosomal proteins play a key role in the regulation of gene expression, the exact manner in which they interact with the genome to initiate, modify, or augment the transcription of specific RNA molecules remains to be resolved.
Source
Science. 1974 Mar 1;183(127):817-24.
Journal/Book/Conference Title
Science (New York, N.Y.)
Related Resources
PubMed ID
4359338
Repository Citation
Stein GS, Spelsberg TC, Kleinsmith LJ. (1974). Nonhistone chromosomal proteins and gene regulation. Stein, Stein, Lian, vanWijnen Lab Publications. Retrieved from https://escholarship.umassmed.edu/stein/220