Title
Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells
UMMS Affiliation
Department of Cell Biology
Publication Date
1-1-1975
Document Type
Article
Subjects
DNA Nucleotidyltransferases; DNA, Neoplasm; Fibroblasts; Fluorides; Hela Cells; Heparin; Iodoacetates; Leucine; Malonates; Mechlorethamine; Neoplasm Proteins; Nucleoproteins; Tryptophan; Vitamin K
Disciplines
Cell Biology
Abstract
Effects of the SH inhibitor sodium iodoacetate, alone and with adjuncts menadiol diphosphate, sodium malonate, sodium fluoride and heparin, on incorporation of tryptophane-3 H into nonhistone chromosomal proteins of HeLa cells were examined. The drugs block incorporation of tryptophane-3 H into nonhistone chromosomal proteins far more than incorporation of leucine-3 H into total cellular proteins. Drug effects on thymidine phosphorylation and DNA synthesis in HeLa cells exceed corresponding effects on fibroblasts from normal healing wounds.
Source
Oncology. 1975;32(5-6):291-301.
Journal/Book/Conference Title
Oncology
Related Resources
PubMed ID
1228540
Repository Citation
Knock, F. E.; Stein, Gary S.; Davis, Jeudi; Galt, R. M.; Oester, Y. T.; and Sylvester, R., "Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells" (1975). Stein, Stein, Lian, vanWijnen Lab Publications. 215.
https://escholarship.umassmed.edu/stein/215