Title
Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells
UMMS Affiliation
Department of Cell Biology
Publication Date
1975-01-01
Document Type
Article
Subjects
DNA Nucleotidyltransferases; DNA, Neoplasm; Fibroblasts; Fluorides; Hela Cells; Heparin; Iodoacetates; Leucine; Malonates; Mechlorethamine; Neoplasm Proteins; Nucleoproteins; Tryptophan; Vitamin K
Disciplines
Cell Biology
Abstract
Effects of the SH inhibitor sodium iodoacetate, alone and with adjuncts menadiol diphosphate, sodium malonate, sodium fluoride and heparin, on incorporation of tryptophane-3 H into nonhistone chromosomal proteins of HeLa cells were examined. The drugs block incorporation of tryptophane-3 H into nonhistone chromosomal proteins far more than incorporation of leucine-3 H into total cellular proteins. Drug effects on thymidine phosphorylation and DNA synthesis in HeLa cells exceed corresponding effects on fibroblasts from normal healing wounds.
Source
Oncology. 1975;32(5-6):291-301.
Journal/Book/Conference Title
Oncology
Related Resources
PubMed ID
1228540
Repository Citation
Knock FE, Stein GS, Davis J, Galt RM, Oester YT, Sylvester R. (1975). Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells. Stein, Stein, Lian, vanWijnen Lab Publications. Retrieved from https://escholarship.umassmed.edu/stein/215