The effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts
Department of Cell Biology
Aged; Cell Line; *Cell Transformation, Neoplastic; DNA Replication; Electrophoresis, Polyacrylamide Gel; Histones; Humans; Infant, Newborn; Molecular Weight; Phosphates; Simian virus 40
The composition and metabolism of chromosomal proteins-histones and nonhistones chromosomal proteins-were examined in normal and SV40 transformed 3T3 mouse cells. Variations were observed, many of which were similar to those previously reported for normal and SV40 transformed W138 human diploid fibroblasts. The possible implications of these viral induced changes in the protein component of the genome for the phenotypic modifications which occur in transformed cells are discussed.
Cell Differ. 1976 Jul;5(2):83-96.
Krause, M. O.; Noonan, K. D.; Kleinsmith, Lewis J.; and Stein, Gary S., "The effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts" (1976). Stein, Stein, Lian, vanWijnen Lab Publications. 198.