Activation of histone gene transcription by nonhistone chromosomal phosphoproteins

Judith A. Thompson, University of Florida
Janet L. Stein, University of Massachusetts Medical School
Lewis J. Kleinsmith, University of Michigan
Gary S. Stein, University of Massachusetts Medical School

Abstract

Hybridization analysis of RNA transcripts from HeLa S3 cell chromatin to histone complementary DNA indicates that a chromosomal phosphoprotein fraction activates transcription of histone messenger RNA sequences in vitro with chromatin from a phase in the cell cycle when histone genes are normally silent.