Regulation of specific genes during the cell cycle. Utilization of homologous cDNAs and cloned sequences for studying histone gene expression in human cells

UMMS Affiliation

Department of Cell Biology

Publication Date


Document Type



Base Sequence; *Cell Cycle; Chromosomal Proteins, Non-Histone; Cloning, Molecular; *Gene Expression Regulation; Histones; Humans; Interphase; Models, Genetic; Nucleic Acid Hybridization; RNA, Messenger; Transcription, Genetic


Cell Biology


Evidence for differential gene expression during the cell cycle and approaches for studying cell-cycle-stage specific gene expression are summarized. Attention is focused on regulation of histone gene expression during the cell cycle of continuously dividing cells and after stimulation of nondividing cells to proliferate. The level(s) at which control of histone gene expression occurs and the possible involvement of chromosomal proteins in the regulation of histone gene expression are discussed. The preparation of cloned human histone sequences and their use in studying the structural and functional properties of human histone genes are presented. Index Entries: Cell cycle, gene regulation during; gene regulation, during the cell cycle; regulation of specific genes, during the cell cycle; DNAs, homologous, and histone gene expression; cloned DNAs, and histone gene expression; histone gene expression; gene expression, histone; cloned human histone sequences.

DOI of Published Version



Cell Biophys. 1980 Dec;2(4):291-314. Link to article on publisher's site

Journal/Book/Conference Title

Cell biophysics

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Link to Article in PubMed

PubMed ID