Title
Regulation of specific genes during the cell cycle. Utilization of homologous cDNAs and cloned sequences for studying histone gene expression in human cells
UMMS Affiliation
Department of Cell Biology
Publication Date
1980-12-01
Document Type
Article
Subjects
Base Sequence; *Cell Cycle; Chromosomal Proteins, Non-Histone; Cloning, Molecular; *Gene Expression Regulation; Histones; Humans; Interphase; Models, Genetic; Nucleic Acid Hybridization; RNA, Messenger; Transcription, Genetic
Disciplines
Cell Biology
Abstract
Evidence for differential gene expression during the cell cycle and approaches for studying cell-cycle-stage specific gene expression are summarized. Attention is focused on regulation of histone gene expression during the cell cycle of continuously dividing cells and after stimulation of nondividing cells to proliferate. The level(s) at which control of histone gene expression occurs and the possible involvement of chromosomal proteins in the regulation of histone gene expression are discussed. The preparation of cloned human histone sequences and their use in studying the structural and functional properties of human histone genes are presented. Index Entries: Cell cycle, gene regulation during; gene regulation, during the cell cycle; regulation of specific genes, during the cell cycle; DNAs, homologous, and histone gene expression; cloned DNAs, and histone gene expression; histone gene expression; gene expression, histone; cloned human histone sequences.
DOI of Published Version
10.1007/BF02785095
Source
Cell Biophys. 1980 Dec;2(4):291-314. Link to article on publisher's site
Journal/Book/Conference Title
Cell biophysics
Related Resources
PubMed ID
6163542
Repository Citation
Stein GS, Stein JL, Marashi F, Parker MI, Sierra LF. (1980). Regulation of specific genes during the cell cycle. Utilization of homologous cDNAs and cloned sequences for studying histone gene expression in human cells. Stein, Stein, Lian, vanWijnen Lab Publications. https://doi.org/10.1007/BF02785095. Retrieved from https://escholarship.umassmed.edu/stein/170