Title
Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner
UMMS Affiliation
Department of Cell Biology
Publication Date
1982-02-05
Document Type
Article
Subjects
*Cell Cycle; Cell Nucleus; Cytarabine; Cytoplasm; Female; Hela Cells; Histones; Humans; Protein Biosynthesis; Transcription, Genetic
Disciplines
Cell Biology
Abstract
The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone genes, were present in the cytoplasm of S phase but not G1 cells.
Source
Science. 1982 Feb 5;215(4533):683-5.
Journal/Book/Conference Title
Science (New York, N.Y.)
Related Resources
PubMed ID
7058333
Repository Citation
Marashi F, Baumbach LL, Rickles R, Sierra F, Stein JL, Stein GS. (1982). Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner. Stein, Stein, Lian, vanWijnen Lab Publications. Retrieved from https://escholarship.umassmed.edu/stein/161