Title
Selective expression of histone genes in mouse-human hybrid cells
UMMS Affiliation
Department of Cell Biology
Publication Date
1985-08-01
Document Type
Article
Subjects
Animals; *Gene Expression Regulation; Histones; Humans; Hybrid Cells; Mice; Protein Processing, Post-Translational; RNA, Messenger
Disciplines
Cell Biology
Abstract
Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.
Source
Exp Cell Res. 1985 Aug;159(2):280-6.
Journal/Book/Conference Title
Experimental cell research
Related Resources
PubMed ID
4029271
Repository Citation
Marashi, Farhad; Croce, Carlo M.; Stein, Janet L.; and Stein, Gary S., "Selective expression of histone genes in mouse-human hybrid cells" (1985). Stein, Stein, Lian, vanWijnen Lab Publications. 141.
https://escholarship.umassmed.edu/stein/141