Transcriptional control of vitamin D-regulated proteins

UMMS Affiliation

Department of Cell Biology



Document Type


Medical Subject Headings

Animals; Base Sequence; DNA; Gene Expression Regulation; Humans; Molecular Sequence Data; Proteins; Transcription, Genetic; Vitamin D


Cell Biology


Vitamin D is a physiological regulator of gene transcription associated with control of a broad spectrum of biological processes that include but is not restricted to growth, differentiation and calcium-mediated homeostatic control. Transcriptional regulation is mediated by sequence-specific interactions of a 1,25(OH)2D3-vitamin D receptor-accessory factor complex with vitamin D responsive elements (VDRE) residing in the promoters of hormone responsive genes. Functioning primarily as a transcription enhancer, activity at the VDRE is controlled by diverse and integrated cellular signalling pathways acting synergistically and/or antagonistically with a series of basal regulatory elements and other hormone regulated sequences that are components of modularly organized vitamin D-responsive gene promoters. Molecular mechanisms that integrate the activities at promoter elements contributing to vitamin D-related transcriptional control include overlapping transcription factor binding domains within regulatory elements and cooperative activities at independent regulatory sequences that determine the level of vitamin D responsiveness.

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Citation: J Cell Biochem. 1992 May;49(1):37-45. Link to article on publisher's site

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