Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia
Authors
Dickson, Eric W.Heard, Stephen O.
Chu, Benson
Fraire, Armando E.
Brueggemann, Angela B.
Doern, Gary V.
Document Type
Journal ArticlePublication Date
1998-02-03Keywords
AnimalsFluorocarbons
Male
Penicillin G
Pneumonia, Pneumococcal
Rats
Rats, Wistar
*Respiration, Artificial
Anesthesiology
Life Sciences
Medicine and Health Sciences
Respiratory Tract Diseases
Surgery
Metadata
Show full item recordAbstract
BACKGROUND: Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. METHODS: Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after infection were placed into one of five groups, each containing 15 rats. The groups were (1) no treatment, (2) one intramuscular injection of penicillin G benzathine (200,000 U), (3) partial liquid ventilation with FC-77, (4) partial liquid ventilation with FC-77 and a single intramuscular dose of penicillin G benzathine (200,000 U), and (5) gas ventilation. Animals were observed every 24 h for survival. RESULTS: All untreated or gas-ventilated animals or animals that received only partial liquid ventilation were dead by 7 days. Those receiving only partial liquid ventilation survived longer than untreated controls, but ultimately all succumbed by day 7. Survival was 40% for penicillin-treated rats compared with controls (P < 0.05) and 80% for animals treated with both partial liquid ventilation and penicillin versus antibiotic alone (P < 0.05). CONCLUSIONS: These observations suggest that partial liquid ventilation with perfluorocarbon in combination with antibiotic administration may be an effective therapeutic modality in pneumococcal pneumonia.Source
Anesthesiology. 1998 Jan;88(1):218-23.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/49421PubMed ID
9447875Notes
Medical student Eric Dickson participated in this study as part of the Senior Scholars research program.