Senior Scholars Program

Title

Penile calciphylaxis: A retrospective case-control study

UMMS Affiliation

Department of Dermatology; School of Medicine; Senior Scholars Program

Faculty Mentor

Daniela Kroshinsky

Publication Date

2020-05-15

Document Type

Article

Disciplines

Dermatology | Medical Education | Nutritional and Metabolic Diseases | Pathological Conditions, Signs and Symptoms

Abstract

BACKGROUND: Calciphylaxis is a rare disorder characterized by skin necrosis caused by calcium deposition within vessels, thrombosis, and subsequent tissue ischemia. Penile involvement may rarely occur.

OBJECTIVE: To identify risk factors, diagnosis, management, and mortality of patients with penile calciphylaxis.

METHODS: A retrospective medical record review was conducted of 16 patients with penile calciphylaxis treated at 2 large urban tertiary care centers between January 2001 and December 2019. A control group of 44 male patients with nonpenile calciphylaxis at the same institution was included.

RESULTS: The median survival of patients with penile calciphylaxis was 3.8 months (interquartile range, 27.0 months). Mortality was 50% at 3 months and 62.5% at 6 months for penile calciphylaxis, and 13.6% at 3 months and 29.5% at 6 months for controls (P = .008). Patients with penile calciphylaxis were less likely to be obese (P = .04) but more likely to have hyperparathyroidism (P = .0003) and end-stage renal disease (P = .049).

LIMITATIONS: Retrospective study design and small sample size.

CONCLUSIONS: This study further defines the disease course of penile calciphylaxis, which has high mortality. Imaging may be used to aid diagnosis. Risk factors include end-stage renal disease, hyperparathyroidism, and normal body mass index.

Keywords

calciphylaxis, diagnosis, management, outcomes, penile, risk factors

DOI of Published Version

10.1016/j.jaad.2020.05.042

Source

Gabel C, Chakrala T, Shah R, Danesh MJ, Dobry AS, Garza-Mayers AC, Ko LN, Nguyen E, St John J, Walls AC, Nigwekar SU, Song PI, Kroshinsky D. Penile calciphylaxis: A retrospective case-control study. J Am Acad Dermatol. 2020 May 15:S0190-9622(20)30906-3. doi: 10.1016/j.jaad.2020.05.042. Epub ahead of print. PMID: 32422224. Link to article on publisher's site

Journal/Book/Conference Title

Journal of the American Academy of Dermatology

Comments

Colleen Gabel participated in this study as a medical student in the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

32422224

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