Penile calciphylaxis: A retrospective case-control study
Department of Dermatology; School of Medicine; Senior Scholars Program
Dermatology | Medical Education | Nutritional and Metabolic Diseases | Pathological Conditions, Signs and Symptoms
BACKGROUND: Calciphylaxis is a rare disorder characterized by skin necrosis caused by calcium deposition within vessels, thrombosis, and subsequent tissue ischemia. Penile involvement may rarely occur.
OBJECTIVE: To identify risk factors, diagnosis, management, and mortality of patients with penile calciphylaxis.
METHODS: A retrospective medical record review was conducted of 16 patients with penile calciphylaxis treated at 2 large urban tertiary care centers between January 2001 and December 2019. A control group of 44 male patients with nonpenile calciphylaxis at the same institution was included.
RESULTS: The median survival of patients with penile calciphylaxis was 3.8 months (interquartile range, 27.0 months). Mortality was 50% at 3 months and 62.5% at 6 months for penile calciphylaxis, and 13.6% at 3 months and 29.5% at 6 months for controls (P = .008). Patients with penile calciphylaxis were less likely to be obese (P = .04) but more likely to have hyperparathyroidism (P = .0003) and end-stage renal disease (P = .049).
LIMITATIONS: Retrospective study design and small sample size.
CONCLUSIONS: This study further defines the disease course of penile calciphylaxis, which has high mortality. Imaging may be used to aid diagnosis. Risk factors include end-stage renal disease, hyperparathyroidism, and normal body mass index.
calciphylaxis, diagnosis, management, outcomes, penile, risk factors
DOI of Published Version
Gabel C, Chakrala T, Shah R, Danesh MJ, Dobry AS, Garza-Mayers AC, Ko LN, Nguyen E, St John J, Walls AC, Nigwekar SU, Song PI, Kroshinsky D. Penile calciphylaxis: A retrospective case-control study. J Am Acad Dermatol. 2020 May 15:S0190-9622(20)30906-3. doi: 10.1016/j.jaad.2020.05.042. Epub ahead of print. PMID: 32422224. Link to article on publisher's site
Journal of the American Academy of Dermatology
Gabel, Colleen; Chakrala, Teja; Shah, Radhika; Danesh, Melissa J.; Dobry, Allison S.; Garza-Mayers, Anna Cristina.; Ko, Lauren N.; Nguyen, Emily; St. John, Jessica; Walls, Andrew C.; Nigwekar, Sagar U.; Song, Philip I.; and Kroshinsky, Daniela, "Penile calciphylaxis: A retrospective case-control study" (2020). University of Massachusetts Medical School. Senior Scholars Program. Paper 287.