Heterogeneity and hypothesis testing in neuropsychiatric illness

UMMS Affiliation

Shriver Center



Document Type


Medical Subject Headings

Genetic Heterogeneity; Neuropsychiatry; Neuropsychological Tests


Mental and Social Health | Neuroscience and Neurobiology | Psychiatry and Psychology


The confounding effects of heterogeneity in biological psychiatry and psychiatric genetics have been widely discussed in the literature. We suggest an approach in which heterogeneity may be put to use in hypothesis testing, and may find application in evaluation of the Crespi & Badcock (C&B) imprinting hypothesis. Here we consider three potential sources of etiologic subtypes for analysis.

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Citation: Deutsch, C. K., Ludwig, W. W., & McIlvane, W. J. (2008). Heterogeneity and hypothesis testing in neuropsychiatric illness. Behavioral and Brain Sciences, 31, 266-267. DOI: 10.1017/S0140525X08004275