RNA Therapeutics Institute Publications

 
The RNA Therapeutics Institute (RTI) at the University of Massachusetts Medical School was founded in 2009 and became an academic department in 2016, chaired by Phillip D. Zamore, Ph.D. The RTI is dedicated to leveraging the strong RNA biology and clinical research communities at UMMS to develop novel therapies for which RNA is the therapeutic target or modality. The RNA Therapeutics Institute faculty are recognized as scientific trailblazers, and include a Nobel Laureate, a Gairdner Prize recipient, the 2018 RNA Society early and mid-career award recipients, and two Howard Hughes Medical Institute Investigators. This collection showcases journal articles and other publications authored by RTI faculty and researchers.

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Publications from 2012

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Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes, Stephan Singer, Ruiying Zhao, Anthony M. Barsotti, Anette Ouwehand, Mina Fazollahi, Elias Coutavas, Kai Breuhahn, Olaf Neumann, Thomas Longerich, Tobias Pusterla, Maureen A. Powers, Keith M. Giles, Peter J. Leedman, Jochen Hess, David Grunwald, Harmen J. Bussemaker, Robert H. Singer, Peter Schirmacher, and Carol Prives

Publications from 2011

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Structural aspects of translation termination on the ribosome, Andrei A. Korostelev

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Molecular Mechanisms of piRNA Biogenesis and Function in Drosophila: A Dissertation, Chengjian Li

Publications from 2010

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Endogenous Small RNAs in the Drosophila Soma: A Dissertation, Megha Ghildiyal

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Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation, Jessica J. Vasale

Publications from 2008

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Autonomy and robustness of translocation through the nuclear pore complex: a single-molecule study, Thomas Dange, David Grunwald, Antje Grunwald, Reiner Peters, and Ulrich Kubitscheck

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Dissecting Small RNA Loading Pathway in Drosophila melanogaster: A Dissertation, Tingting Du

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Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation, Michael D. Horwich

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A Study of Cell Polarity and Fate Specification in Early C. Elegans Embryos: A Dissertation, Soyoung Kim

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Conversion of red fluorescent protein into a bright blue probe, Oksana M. Subach, Illia S. Gundorov, Masami Yoshimura, Fedor V. Subach, Jinghang Zhang, David Grunwald, Ekaterina A. Souslova, Dmitriy M. Chudakov, and Vladislav V. Verkhusha

Publications from 2007

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Understanding Assembly of AGO2 RISC: the RNAi enzyme: a Dissertation, Christian B. Matranga

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The Argonaute Family of Genes in Caenorhabditis Elegans: a Dissertation, Erbay Yigit

Publications from 2006

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Identification of Novel (RNAi Deficient) Genes in C. elegans: A Dissertation, Chun-Chieh G. Chen

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Intranuclear binding kinetics and mobility of single native U1 snRNP particles in living cells, David Grunwald, Beatrice Spottke, Volker Buschmann, and Ulrich Kubitscheck

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RNA Silencing Pathways in Schizosaccharomyces pombe and Drosophila melanogaster: A Dissertation, Alla A. Sigova

Publications from 2005

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Analysis of Polarity Signaling in Both Early Embryogenesis and Germline Development in C. Elegans: A Dissertation, Yanxia Bei

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A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster: A Dissertation, Benjamin Haley

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Nuclear transport of single molecules: dwell times at the nuclear pore complex, Ulrich Kubitscheck, David Grunwald, Andreas Hoekstra, Daniel Rohleder, Thorsten Kues, Jan Peter Siebrasse, and Reiner Peters

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Biochemical Mechanism of RNA Interference in Higher Organisms: A Dissertation, Dianne S. Schwarz

Publications from 2003

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Conserved Nucleosome Remodeling/Histone Deacetylase Complex and Germ/Soma Distinction in C. elegans: A Dissertation, Yingdee Unhavaithaya

Publications from 2001

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Analysis of RNA Interference in C. elegans: A Dissertation, Alla Grishok

Publications from 1999

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Analysis of Cell Polarity Signaling in C. elegans: A Dissertation, Christian Ernest Rocheleau