Deconstructing transport-distribution reconstruction in the nuclear-pore complex
RNA Therapeutics Institute; Graduate School of Biomedical Sciences
Letter to the Editor
Amino Acids, Peptides, and Proteins | Biochemistry, Biophysics, and Structural Biology
Nuclear-pore complexes (NPCs) span the nuclear envelope and mediate bidirectional transport between the nucleus and cytoplasm. Macromolecules (>40 kDa) require transport receptors to transit the NPC efficiently, whereas smaller molecules diffuse through the NPC passively. The mechanism through which the semipermeable barrier at the center of the NPC regulates selective transport is unknown. Aiming to elucidate this mechanism, Yang and colleagues have investigated spatial cargo distribution within the NPC2 by using single-point edge-excitation subdiffraction (SPEED) microscopy.
DOI of Published Version
Nat Struct Mol Biol. 2018 Dec;25(12):1061-1062. doi: 10.1038/s41594-018-0161-2. Epub 2018 Dec 5. Link to article on publisher's site
Nature structural and molecular biology
Tu, Li-Chun; Huisman, Maximiliaan; Chung, Yu-Chieh; Smith, Carlas; and Grünwald, David, "Deconstructing transport-distribution reconstruction in the nuclear-pore complex" (2018). RNA Therapeutics Institute Publications. 53.