RNA Therapeutics Institute Publications

Title

Deconstructing transport-distribution reconstruction in the nuclear-pore complex

UMMS Affiliation

RNA Therapeutics Institute; Graduate School of Biomedical Sciences

Publication Date

2018-12-05

Document Type

Letter to the Editor

Disciplines

Amino Acids, Peptides, and Proteins | Biochemistry, Biophysics, and Structural Biology

Abstract

Nuclear-pore complexes (NPCs) span the nuclear envelope and mediate bidirectional transport between the nucleus and cytoplasm. Macromolecules (>40 kDa) require transport receptors to transit the NPC efficiently, whereas smaller molecules diffuse through the NPC passively. The mechanism through which the semipermeable barrier at the center of the NPC regulates selective transport is unknown. Aiming to elucidate this mechanism, Yang and colleagues have investigated spatial cargo distribution within the NPC2 by using single-point edge-excitation subdiffraction (SPEED) microscopy.

DOI of Published Version

10.1038/s41594-018-0161-2

Source

Nat Struct Mol Biol. 2018 Dec;25(12):1061-1062. doi: 10.1038/s41594-018-0161-2. Epub 2018 Dec 5. Link to article on publisher's site

Journal/Book/Conference Title

Nature structural and molecular biology

Related Resources

Link to Article in PubMed

PubMed ID

30518848

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