RNA Therapeutics Institute Publications

Title

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

UMMS Affiliation

RNA Therapeutics Institute

Publication Date

1-1-2018

Document Type

Article

Disciplines

Biochemistry, Biophysics, and Structural Biology | Cell and Developmental Biology | Ecology and Evolutionary Biology | Genetics and Genomics | Therapeutics

Abstract

In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable elements (TEs), protecting the germline from genomic instability and mutation. piRNAs have been detected in the soma in a few animals, but these are believed to be specific adaptations of individual species. Here, we report that somatic piRNAs were probably present in the ancestral arthropod more than 500 million years ago. Analysis of 20 species across the arthropod phylum suggests that somatic piRNAs targeting TEs and messenger RNAs are common among arthropods. The presence of an RNA-dependent RNA polymerase in chelicerates (horseshoe crabs, spiders and scorpions) suggests that arthropods originally used a plant-like RNA interference mechanism to silence TEs. Our results call into question the view that the ancestral role of the piRNA pathway was to protect the germline and demonstrate that small RNA silencing pathways have been repurposed for both somatic and germline functions throughout arthropod evolution.

DOI of Published Version

10.1038/s41559-017-0403-4

Source

Nat Ecol Evol. 2018 Jan;2(1):174-181. doi: 10.1038/s41559-017-0403-4. Epub 2017 Dec 4. Link to article on publisher's site

Journal/Book/Conference Title

Nature ecology and evolution

Related Resources

Link to Article in PubMed

PubMed ID

29203920

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