RNA Therapeutics Institute Publications

Title

RNA interference-mediated antiviral defense in insects

UMMS Affiliation

RNA Therapeutics Institute

Publication Date

2015-04-01

Document Type

Article

Disciplines

Biochemistry, Biophysics, and Structural Biology | Cell and Developmental Biology | Entomology | Genetics and Genomics | Therapeutics

Abstract

Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.

DOI of Published Version

10.1016/j.cois.2015.01.006

Source

Curr Opin Insect Sci. 2015 Apr 1;8:111-120. doi: 10.1016/j.cois.2015.01.006. Link to article on publisher's site

Journal/Book/Conference Title

Current opinion in insect science

Related Resources

Link to Article in PubMed

PubMed ID

26034705

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