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UMass Chan Affiliations
RNA Therapeutics InstituteDocument Type
Journal ArticlePublication Date
2015-04-01Keywords
Biochemistry, Biophysics, and Structural BiologyCell and Developmental Biology
Entomology
Genetics and Genomics
Therapeutics
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Show full item recordAbstract
Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.Source
Curr Opin Insect Sci. 2015 Apr 1;8:111-120. doi: 10.1016/j.cois.2015.01.006. Link to article on publisher's site
DOI
10.1016/j.cois.2015.01.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48813PubMed ID
26034705Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.cois.2015.01.006