RNA Therapeutics Institute Publications

 
The RNA Therapeutics Institute (RTI) at the University of Massachusetts Medical School was founded in 2009 and became an academic department in 2016, chaired by Phillip D. Zamore, Ph.D. The RTI is dedicated to leveraging the strong RNA biology and clinical research communities at UMMS to develop novel therapies for which RNA is the therapeutic target or modality. The RNA Therapeutics Institute faculty are recognized as scientific trailblazers, and include a Nobel Laureate, a Gairdner Prize recipient, the 2018 RNA Society early and mid-career award recipients, and two Howard Hughes Medical Institute Investigators. This collection showcases journal articles and other publications authored by RTI faculty and researchers.

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Publications from 2018

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Bayesian nonparametric discovery of isoforms and individual specific quantification, Derek Aguiar, Li-Fang Cheng, Bianca Dumitrascu, Fantine Mordelet, Athma A. Pai, and Barbara E. Engelhardt

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NmeCas9 is an intrinsically high-fidelity genome editing platform, Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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Synergistic assembly of human pre-spliceosomes across introns and exons, Joerg E. Braun, Larry J. Friedman, Jeff Gelles, and Melissa J. Moore

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Maelstrom Represses Canonical RNA Polymerase II Transcription in Drosophila Dual-Strand piRNA Clusters, Timothy H. Chang

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Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling, Weijun Chen, Jill E. Moore, Hakan Ozadam, Hennady P. Shulha, Nicholas Rhind, Zhiping Weng, and Melissa J. Moore

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Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers, Yu Fu, Pei-Hsuan Wu, Timothy J. Beane, Phillip D. Zamore, and Zhiping Weng

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The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology, Yu Fu, Yujing Yang, Han Zhang, Gwen Farley, Junling Wang, Kaycee A. Quarles, Zhiping Weng, and Phillip D. Zamore

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C-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer

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C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2, Xin D. Gao, Li-Chun Tu, Aamir Mir, Tomas Rodriguez, Yue-He Ding, John D. Leszyk, Job Dekker, Scott A. Shaffer, Lihua Julie Zhu, Scot A. Wolfe, and Erik J. Sontheimer (Nature methods, 5-7-2018)

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Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons, Reka A. Haraszti

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo, Matthew R. Hassler, Anton A. Turanov, Julia F. Alterman, Reka A. Haraszti, Andrew H. Coles, Maire F. Osborn, Dimas Echeverria, Mehran Nikan, William E. Salomon, Loic Roux, Bruno M. D. C. Godinho, Sarah M. Davis, David V. Morrissey, Phillip D. Zamore, S. Ananth Karumanchi, Melissa J. Moore, Neil Aronin, and Anastasia Khvorova

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Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy, Jiaxin Hu, Ziye Rong, Xin Gong, Zhengyang Zhou, Vivek K. Sharma, Chao Xing, Jonathan K. Watts, David R. Corey, and V. Vinod Mootha

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All-in-One Adeno-associated Virus Delivery and Genome Editing by Neisseria meningitidis Cas9 in vivo, Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, and Erik J. Sontheimer

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Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements, Samuel H. Lewis, Yujing Yang, Phillip D. Zamore, and Francis M. Jiggins

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Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs, Yi Lu, Phillip W. L. Tai, Jianzhong Ai, Dominic J. Gessler, Qin Su, Xieyi Yao, Qiang Zheng, Phillip D. Zamore, Xun Xu, and Guangping Gao

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Higher-Order Organization Principles of Pre-translational mRNPs, Mihir Metkar, Hakan Ozadam, Bryan R. Lajoie, Maxim Imakaev, Leonid A. Mirny, Job Dekker, and Melissa J. Moore

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Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing, Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts, and Erik J. Sontheimer

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Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast, Diego J. Paez-Moscoso, Lili Pan, Rutendo F. Sigauke, Morgan R. Schroeder, Wen Tang, and Peter Baumann

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Numerous recursive sites contribute to accuracy of splicing of long introns in flies, Athma A. Pai, Joseph Paggi, Karen Adelman, and Christopher B. Burge

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A Fresh Look at Huntingtin mRNA Processing in Huntington's Disease, Lindsay S. Romo, Emily S. Mohn, and Neil Aronin

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Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain, Juan Sanchez-Ramos, Shijie Song, Xiaoyuan Kong, Parastou Foroutan, Gary Martinez, William Dominguez-Viqueria, Shyam Mohapatra, Subhra Mohapatra, Reka A. Haraszti, Anastasia Khvorova, Neil Aronin, and Vasyl Sava

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The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans, Meetu Seth, Masaki Shirayama, Wen Tang, En-Zhi Shen, Shikui Tu, Heng-Chi Lee, Zhiping Weng, and Craig C. Mello

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Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline, En-Zhi Shen, Hao Chen, Ahmet R. Ozturk, Shikui Tu, Masaki Shirayama, Wen Tang, Yue-He Ding, Si-Yuan Dai, Zhiping Weng, and Craig C. Mello

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An Automated Bayesian Pipeline for Rapid Analysis of Single-Molecule Binding Data, Carlas Smith, Karina Jouravleva, Maximiliaan Huisman, Samson M. Jolly, Phillip D. Zamore, and David Grünwald

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In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency, Chun-Qing Song, Dan Wang, Tingting Jiang, Kevin O'Connor, Qiushi Tang, Lingling Cai, Xiangrui Li, Zhiping Weng, Hao Yin, Guangping Gao, Christian Mueller, Terence R. Flotte, and Wen Xue

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Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics, Barry L. Stoddard, Anastasia Khvorova, David R. Corey, William S. Dynan, and Keith R. Fox

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Mechanism of premature translation termination on a sense codon, Egor Svidritskiy, Garbriel Demo, and Andrei A. Korostelev

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A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans, Wen Tang, Meetu Seth, Shikui Tu, En-Zhi Shen, Qian Li, Masaki Shirayama, Zhiping Weng, and Craig C. Mello

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Partial DNA-guided Cas9 enables genome editing with reduced off-target activity, Hao Yin, Chun-Qing Song, Sneha Suresh, Suet-Yan Kwan, Qiongqiong Wu, Stephen Walsh, Junmei Ding, Roman L. Bogorad, Lihua Julie Zhu, Scot A. Wolfe, Victor Koteliansky, Wen Xue, Robert Langer, and Daniel G. Anderson

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A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals, Phillip D. Zamore, Ildar Gainetdinov, Cansu Colpan, and Katharine Cecchini

Publications from 2017

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A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics, Julia F. Alterman, Andrew H. Coles, Lauren M. Hall, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia, Ami Ashar-Patel, Yasin Kaymaz, Augustine Rajakumar, Jeffrey A. Bailey, S. Ananth Karumanchi, and Melissa J. Moore

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A common class of transcripts with 5'-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification, Can Cenik, Hon Nian Chua, Guramrit Singh, Abdalla Akef, Michael P. Snyder, Alexander F. Palazzo, Melissa J. Moore, and Frederick P. Roth

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Structure of RNA polymerase bound to ribosomal 30S subunit, Gabriel Demo, Aviram Rasouly, Nikita Vasilyev, Vladimir Svetlov, Anna B. Loveland, Ruben Diaz-Avalos, Nikolaus Grigorieff, Evgeny Nudler, and Andrei A. Korostelev

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Mechanism of ribosome rescue by ArfA and RF2, Gabriel Demo, Egor Svidritskiy, Rohini Madireddy, Ruben Diaz-Avalos, Timothy Grant, Nikolaus Grigorieff, Duncan Sousa, and Andrei A. Korostelev

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The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans, Don B. Gammon, Takao Ishidate, Lichao Li, Weifeng Gu, Neal S. Silverman, and Craig C. Mello

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Protocol for analyzing protein ensemble structures from chemical cross-links using DynaXL, Zhou Gong, Zhu Liu, Xu Dong, Yue-He Ding, Meng-Qiu Dong, and Chun Tang

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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System, Reka A. Haraszti, Andrew H. Coles, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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5-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo, Reka A. Haraszti, Loic Roux, Andrew H. Coles, Anton A. Turanov, Julia F. Alterman, Dimas Echeverria, Bruno M. D. C. Godinho, Neil Aronin, and Anastasia Khvorova

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A Broad-Spectrum Inhibitor of CRISPR-Cas9, Lucas B. Harrington, Kevin W. Doxzen, Alireza Edraki, Nadia Amrani, Erik J. Sontheimer, and Jennifer A. Doudna

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Fluorescence polarization control for on-off switching of single molecules at cryogenic temperatures, Christiaan Hulleman, Maximiliaan Huisman, Robert Moerland, David Grünwald, Sjoerd Stallinga, and Bernd Rieger

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The chemical evolution of oligonucleotide therapies of clinical utility, Anastasia Khvorova and Jonathan K. Watts

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Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine, Cha San Koh, Rohini Madireddy, Timothy J. Beane, Phillip D. Zamore, and Andrei A. Korostelev

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Involvement of p38-betaTrCP-Tristetraprolin-TNFalpha axis in radiation pneumonitis, Pranathi Meda Krishnamurthy, Shirish Shukla, Paramita Ray, Rohit Mehra, Mukesh K. Nyati, Theodore S. Lawrence, and Dipankar Ray

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Identification of Factors Involved in 18S Nonfunctional Ribosomal RNA Decay and a Method for Detecting 8-oxoguanosine by RNA-Seq, Kelly A. Limoncelli

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Ensemble cryo-EM elucidates the mechanism of translation fidelity, Anna B. Loveland, Gabriel Demo, Nikolaus Grigorieff, and Andrei A. Korostelev

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Visualization of self-delivering hydrophobically modified siRNA cellular internalization, Socheata Ly, Deanna M. Navaroli, Marie-Claire Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. Alterman, Kevin E. Fogarty, Clive Standley, Lawrence Lifshitz, Karl D. Bellve, Matthieu Prot, Dimas Echeverria, Silvia Corvera, and Anastasia Khvorova

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CRISPR-Based DNA Imaging in Living Cells Reveals Cell Cycle-Dependent Chromosome Dynamics, Hanhui Ma, Li-Chun Tu, University of Central Florida, Yu-Chieh Chung, David Grünwald, Shaojie Zhang, and Thoru Pederson

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Infection of Caenorhabditis elegans with Vesicular Stomatitis Virus via Microinjection, Adam Martin, Emily A. Rex, Takao Ishidate, Rueyling Lin, and Don B. Gammon

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A microRNA family exerts maternal control on sex determination in C. elegans, Katherine McJunkin and Victor R. Ambros

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells, James R. C. Miller, Edith L. Pfister, Wanzhao Liu, Ralph Andre, Ulrike Trager, Lori A. Kennington, Kimberly Lo, Sipke Dijkstra, Douglas Macdonald, Gary R. Ostroff, Neil Aronin, and Sarah J. Tabrizi

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Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis, Haiwei Mou, Jill Moore, Sunil K. Malonia, Yingxiang Li, Deniz M. Ozata, Soren Hough, Chun-Qing Song, Jordan L. Smith, Andrew H. Fischer, Zhiping Weng, Michael R. Green, and Wen Xue

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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion, Haiwei Mou, Jordan L. Smith, Lingtao Peng, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Deniz M. Ozata, Yingxiang Li, Charles P. Emerson Jr., Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, and Wen Xue

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Single-molecule FISH in Drosophila muscle reveals location dependent mRNA composition of megaRNPs, Akiko Noma, Carlas Smith, Maximiliaan Huisman, Robert M. Martin, Melissa J. Moore, and David Grünwald

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Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA, Hannah M. Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J. Debacker, Michael P. Moazami, Vivek K. Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi, and Jonathan K. Watts

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Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin, Edith L. Pfister, Kathryn O. Chase, Huaming Sun, Lori A. Kennington, Faith Conroy, Emily S. Johnson, Rachael Miller, Florie Borel, Neil Aronin, and Christian Mueller

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Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease, Edith L. Pfister, Natalie Dinardo, Erica Mondo, Florie Borel, Faith Conroy, Gwladys Gernoux, Lori A. Kennington, Richard P. Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, and Neil Aronin

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Environmental perturbations lead to extensive directional shifts in RNA processing, Allison L. Richards, Donovan Watza, Anthony Findley, Adnan Alazizi, Xiaoquan Wen, Athma A. Pai, Roger Pique-Regi, and Francesca Luca

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Alterations in mRNA 3' UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington's Disease Brains, Lindsay S. Romo, Ami Ashar-Patel, Edith L. Pfister, and Neil Aronin

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miRNAs cooperate in apoptosis regulation during C. elegans development, Ryan Sherrard, Sebastian Luehr, Heinke Holzkamp, Katherine McJunkin, Nadin Memar, and Barbara Conradt

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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

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Inhibition of CRISPR-Cas systems by mobile genetic elements, Erik J. Sontheimer and Alan R. Davidson

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A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma, Tuomas Tammela, Wen Xue, and Tyler Jacks

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Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing, Hao Yin, Chun-Qing Song, Esther Mintzer, Mehmet F. Bolukbasi, Lihua Julie Zhu, Haiwei Mou, Suet-Yan Kwan, Scot A. Wolfe, Wen Xue, and Daniel G. Anderson

Publications from 2016

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Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome, Priyanka D. Abeyrathne, Cha San Koh, Timothy Grant, Nikolaus Grigorieff, and Andrei A. Korostelev

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A Modular Assembly Platform for Rapid Generation of DNA Constructs, Elliot Akama-Garren, Nik Joshi, Tuomas Tammela, Gregory P. Chang, Bethany L. Wagner, Da-Yae Lee, William M. Rideout Iii, Thales Papagiannakopoulos, Wen Xue, and Tyler Jacks

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Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson

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A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes, Michelle A. Carmell, Gregoriy A. Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C. van Wolfswinkel, Kyomi J. Igarashi, Daniel W. Bellott, Michael Nefedov, Peter W. Reddien, George C. Enders, Vladimir N. Uversky, Craig C. Mello, and David C. Page

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A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification, Can Cenik, Hon Nian Chua, Guramrit Singh, Abdalla Akef, Michael P. Snyder, Alexander F. Palazzo, Melissa J. Moore, and Frederick P. Roth

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HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein, Jianbo Chen, Sheikh Abdul Rahman, Olga A. Nikolaitchik, David Grünwald, Luca Sardo, Ryan C. Burdick, Sergey Plisov, Edward Liang, Sheldon Tai, Vinay K. Pathak, and Wei-Shau Hu

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Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector, Sourav Roy Choudhury, Anne F. Harris, Damien J. Cabral, Allison M. Keeler, Jennifer Ferreira, Qin Su, Lorelei Stoica, Neil Aronin, Guangping Gao, and Miguel Sena-Esteves

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Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing, Marie C. Didiot, Lauren M. Hall, Andrew H. Coles, Reka A. Haraszti, Bruno M. D. C. Godinho, Kathryn O. Chase, Socheata Ly, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Neil Aronin, and Anastasia Khvorova

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Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion, Daniel Tianfang Ge, Cindy Tipping, Michael H. Brodsky, and Phillip D. Zamore

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The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4, Megan M. Gnazzo, Eva-Maria E. Uhlemann, Alex R. Villarreal, Masaki Shirayama, Eddie G. Dominguez, and Ahna R. Skop

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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources, Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John D. Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, and Anastasia Khvorova

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Redefining the Translational Status of 80S Monosomes, Erin E. Heyer and Melissa J. Moore

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GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis, Guillaume Jannot, Pascale Michaud, Miguel Quevillon Huberdeau, Louis Morel-Berryman, James A. Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, and Martin J. Simard

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NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548, Hao Ke, Limin Zhao, Xu Feng, Haibo Xu, Li Zou, Qin Yang, Xiaosan Su, Lingtao Peng, and Baowei Jiao

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Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon, Wanzhao Liu, Edith L. Pfister, Lori A. Kennington, Kathryn O. Chase, Christian Mueller, Marian DiFiglia, and Neil Aronin

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Ribosome*RelA structures reveal the mechanism of stringent response activation, Anna B. Loveland, Eugene Bah, Rohini Madireddy, Ying Zhang, Axel F. Brilot, Nikolaus Grigorieff, and Andrei A. Korostelev

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CRISPR-Cas9 nuclear dynamics and target recognition in living cells, Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximiliaan Huisman, Shaojie Zhang, David Grünwald, and Thoru Pederson

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Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow, Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximiliaan Huisman, Shaojie Zhang, David Grünwald, and Thoru Pederson

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Deciphering the Structure and Function of Nuclear Pores Using Single-Molecule Fluorescence Approaches, Siegfried M. Musser and David Grunwald

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain, Mehran Nikan, Maire F. Osborn, Andrew H. Coles, Bruno M. D. C. Godinho, Lauren M. Hall, Reka A. Haraszti, Dimas Echeverria, Neil Aronin, Matthew R. Hassler, and Anastasia Khvorova

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Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism, Mireille Ouimet, Katharine Cecchini, Philip D. Zamore, and Kathryn J. Moore

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Naturally Occurring Off-Switches for CRISPR-Cas9, April Pawluk, Nadia Amrani, Yan Zhang, Bianca Garcia, Yurima Hidalgo-Reyes, Jooyoung Lee, Alireza Edraki, Megha Shah, Erik J. Sontheimer, Karen L. Maxwell, and Alan R. Davidson

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Staufen Negatively Modulates microRNA Activity in Caenorhabditis elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, and Victor R. Ambros

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Functions of Argonaute Proteins in Self Versus Non-Self Recognition in the C. elegans Germline: A Dissertation, Meetu Seth

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Genomic Amplifications Cause False Positives in CRISPR Screens, Ankur Sheel and Wen Xue

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Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice, Chun-Qing Song, Yingxiang Li, Haiwei Mou, Jill Moore, Angela I. Park, Soren Hough, Zachary Kennedy, Andrew H. Fischer, Darryl Conte Jr., Zhiping Weng, and Wen Xue

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Structural Basis for Translation Termination on a Pseudouridylated Stop Codon, Egor Svidritskiy, Rohini Madireddy, and Andrei A. Korostelev

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The RNase PARN-1 Trims piRNA 3' Ends to Promote Transcriptome Surveillance in C. elegans, Wen Tang, Shikui Tu, Heng-Chi Lee, Zhiping Weng, and Craig C. Mello

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MMB-GUI: a fast morphing method demonstrates a possible ribosomal tRNA translocation trajectory, Alex Tek, Andrei A. Korostelev, and Samuel Coulbourn Flores

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RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver, Hao Yin, Roman L. Bogorad, Carmen Barnes, Stephen Walsh, Iris Zhuang, Hidenori Nonaka, Vera Ruda, Satya Kuchimanchi, Lubomir Nechev, Akin Akinc, Wen Xue, Marino Zerial, Robert Langer, Daniel G. Anderson, and Victor Koteliansky

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo, Hao Yin, Chun-Qing Song, Joseph R. Dorkin, Lihua Julie Zhu, Yingxiang Li, Qiongqiong Wu, Angela I. Park, Junghoon Yang, Sneha Suresh, Aizhan Bizhanova, Ankit Gupta, Mehmet Fatih Bolukbasi, Stephen Walsh, Roman L. Bogorad, Guangping Gao, Zhiping Weng, Yizhou Dong, Victor Koteliansky, Scot A. Wolfe, Robert Langer, Wen Xue, and Daniel G. Anderson

Publications from 2015

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain, Julia F. Alterman, Lauren M. Hall, Andrew H. Coles, Matthew R. Hassler, Marie C. Didiot, Kathryn O. Chase, Jasmin Abraham, Emily Sottosanti, Emily S. Johnson, Ellen Sapp, Maire F. Osborn, Marian Difiglia, Neil Aronin, and Anastasia Khvorova

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Integrative analysis of RNA, translation and protein levels reveals distinct regulatory variation across humans, Can Cenik, Elif Sarinay Cenik, Gun W. Byeon, Fabian Grubert, Sophie I. Candille, Damek Spacek, Bilal Alsallakh, Hagen Tilgner, Carlos L. Araya, Hua Tang, Emiliano P. Ricci, and Michael P. Snyder

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Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans, Can Cenik, Elif Sarinay Cenik, Gun W. Byeon, Fabian Grubert, Sophie I. Candille, Damek Spacek, Bilal Alsallakh, Hagen Tilgner, Carlos L. Araya, Hua Tang, Emiliano P. Ricci, and Michael P. Snyder

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Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs, Min-Te Chou, Bo W. Han, Chiung-Po Hsiao, Phillip D. Zamore, Zhiping Weng, and Jui-Hung Hung

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RNA Interference in Caenorhabditis elegans, Darryl Conte Jr., Lesley T. MacNeil, Albertha J. M. Walhout, and Craig C. Mello (Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 1-5-2015)