UMMS Affiliation

Department of Medicine, Division of Rheumatology

Publication Date

2003-07-17

Document Type

Response or Comment

Subjects

Animals; Arthritis, Rheumatoid; Disease Models, Animal; Epitopes; Inflammation; Mice; Mice, Inbred C57BL; Osteopontin; RNA, Messenger; Sialoglycoproteins

Disciplines

Cells | Medical Immunology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.

Keywords

osteopontin, rheumatoid arthritis

Rights and Permissions

Publisher PDF posted as allowed by the publisher's author rights policy at http://static.the-jci.org/content_assets/admin/forms/jcicopyright.pdf.

DOI of Published Version

10.1172/JCI19190

Source

J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical investigation

Comments

At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

12865402

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