Department of Medicine, Division of Rheumatology
Response or Comment
Animals; Arthritis, Rheumatoid; Disease Models, Animal; Epitopes; Inflammation; Mice; Mice, Inbred C57BL; Osteopontin; RNA, Messenger; Sialoglycoproteins
Cells | Medical Immunology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.
osteopontin, rheumatoid arthritis
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DOI of Published Version
J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's site
The Journal of clinical investigation
Gravallese, Ellen M., "Osteopontin: a bridge between bone and the immune system" (2003). Rheumatology Publications and Presentations. 62.