UMMS Affiliation

Department of Medicine, Division of Rheumatology



Document Type

Response or Comment

Medical Subject Headings

Animals; Arthritis, Rheumatoid; Disease Models, Animal; Epitopes; Inflammation; Mice; Mice, Inbred C57BL; Osteopontin; RNA, Messenger; Sialoglycoproteins


Cells | Medical Immunology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases


The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.

Rights and Permissions

Citation: J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's site


At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

Publisher PDF posted as allowed by the publisher's author rights policy at

Related Resources

Link to Article in PubMed


osteopontin, rheumatoid arthritis

PubMed ID



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