UMMS Affiliation

Department of Medicine, Division of Rheumatology

Publication Date


Document Type

Response or Comment


Animals; Arthritis, Rheumatoid; Disease Models, Animal; Epitopes; Inflammation; Mice; Mice, Inbred C57BL; Osteopontin; RNA, Messenger; Sialoglycoproteins


Cells | Medical Immunology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases


The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.


osteopontin, rheumatoid arthritis

Rights and Permissions

Publisher PDF posted as allowed by the publisher's author rights policy at

DOI of Published Version



J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical investigation


At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.