Synovial tissue response to treatment with Campath-1H

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Publication Date


Document Type



Antigens, CD; Antigens, CD19; Antigens, CD20; Antigens, CD3; Antigens, Differentiation, B-Lymphocyte; *Antigens, Neoplasm; Arthritis, Rheumatoid; B-Lymphocyte Subsets; CD4-Positive T-Lymphocytes; *Glycoproteins; Humans; Immunohistochemistry; Knee Prosthesis; Lymphopenia; Paraffin Embedding; Synovial Membrane


Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases


OBJECTIVE: Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.

METHODS: Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.

RESULTS: Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.

CONCLUSION: These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.

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Citation: Arthritis Rheum. 1995 Feb;38(2):254-8. DOI: 10.1002/art.1780380215

Journal/Book/Conference Title

Arthritis and rheumatism


At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID