Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia

UMMS Affiliation

Department of Medicine, Division of Rheumatology



Document Type


Medical Subject Headings

Chromosomes, Human, Pair 3; Cryoglobulinemia; Hepatitis C; Humans; Lymphoproliferative Disorders; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Treatment Outcome; Trisomy; Vasculitis


Hemic and Lymphatic Diseases


A patient with type II cryoglobulinemic vasculitis and hepatitis C virus (HCV) infection presented with a leukemiclike proliferation of B cells bearing marginal zone B-cell phenotypic markers. A partial trisomy 3 (bands 3q11-29) and overexpression of Bcl-2 without t(14;18) translocation was detected in the monoclonal B cells that were classic rheumatoid factor-producing B cells bearing the WA cross-idiotype. Treatment with interferon-alpha produced a complete clinical remission and synchronous marked decreases in viremia and monoclonal B-cell prevalence. This is the first report of partial trisomy 3 and Bcl-2 overexpression in type II cryoglobulinemic vasculitis associated with HCV infection. Further studies of HCV-infected patients with and without type II cryoglobulinemia are required to determine the prevalence and possible physiologic and/or pathophysiologic significance of these findings.

Rights and Permissions

Citation: Blood. 2002 Mar 15;99(6):2259-61. Link to article on publisher's site


At the time of publication, Jonathan Kay was not yet affiliated with the University of Massachusetts Medical School.

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