Wegener's granulomatosis: is biologic therapy useful
Department of Medicine, Division of Rheumatology
Animals; *Biological Therapy; Controlled Clinical Trials as Topic; Disease Models, Animal; Granulomatosis with Polyangiitis; Humans; Immunologic Factors
Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases
Wegener's granulomatosis (WG) is a complex autoimmune disorder that has been transformed from a uniformly lethal process to a chronic disease with a relapsing-remitting course. In the setting of frequent relapses, the need to manage cumulative disease damage and drug toxicities has spurred the identification and development of new potent and directed therapies. Biologic agents, which offer the potential for remission-induction and drug-sparing approaches to treat WG, have been studied in several small, open-label clinical series and one large, randomized, placebo-controlled clinical trial. This article discusses the results of these trials and the potential of these biologic agents to treat WG.
DOI of Published Version
Curr Rheumatol Rep. 2006 Aug;8(4):303-11. 10.1007/s11926-006-0014-6 Link to article on publisher's site
Current rheumatology reports
Sarraf, Pasha; Kay, Jonathan; Friday, Robert P.; and Reginato, Anthony M., "Wegener's granulomatosis: is biologic therapy useful" (2006). Rheumatology Publications and Presentations. 130.