Osteoarticular disorders of renal origin: disease-related and iatrogenic

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Publication Date


Document Type



Amyloidosis; Humans; *Iatrogenic Disease; Kidney Failure, Chronic; Osteoarthritis; Renal Dialysis; beta 2-Microglobulin


Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases


Osteoarticular disorders significantly limit the quality of long-term survival with chronic renal failure. beta 2M amyloidosis is a complication of chronic renal failure that has been recognized mostly in patients receiving long-term haemodialysis. Patients with beta 2M amyloidosis typically present with the triad of shoulder periarthritis, carpal tunnel syndrome, and flexor tenosynovitis of the hands. Other musculoskeletal manifestations of beta 2M amyloidosis include destructive spondyloarthropathy, cervico-occipital pseudotumours, bone cysts, and pathological fractures. At present, only renal transplantation may slow or halt the progession of beta 2M amyloidosis. Crystal-induced arthropathy, most commonly caused by basic calcium phosphate crystals, is an important cause of acute joint inflammation in the patient with renal failure. The incidence of bone and joint infection is increased in patients undergoing dialysis. Haemodialysis and peritoneal dialysis are also associated with an erosive or destructive arthropathy of finger joints, which is not explained by local amyloid deposition.

DOI of Published Version



Baillieres Best Pract Res Clin Rheumatol. 2000 Jun;14(2):285-305. doi:10.1053/berh.2000.0066 Link to article on publisher's site

Journal/Book/Conference Title

Bailliere's best practice and research. Clinical rheumatology


At the time of publication, Jonathan Kay was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID