Current status of nephrogenic systemic fibrosis

UMMS Affiliation

Department of Medicine, Division of Rheumatology



Document Type


Medical Subject Headings

Acute Kidney Injury; Contrast Media; Cytokines; Epidemiologic Methods; Gadolinium; Guideline Adherence; Humans; Nephrogenic Fibrosing Dermopathy; control; *Practice Guidelines as Topic; Renal Insufficiency, Chronic


Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases


Nephrogenic systemic fibrosis (NSF) occurs in patients with advanced chronic kidney disease (CKD) or acute renal failure, most commonly following exposure to gadolinium-based contrast agents (GBCAs). NSF can be debilitating and associated with increased mortality. The putative association of NSF with GBCAs prompted the development of guidelines to limit the use of these contrast agents in at-risk patients. Indeed, the incidence of NSF has decreased dramatically following application of these guidelines, which appears to be the only effective means of decreasing NSF incidence. Thus, increasing clinician awareness of these updated guidelines is important. The present review introduces and compares updated guidelines for GBCA use and discusses the latest advances in the understanding of the pathogenic mechanisms and treatment of NSF. All rights reserved.

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Citation: Clin Radiol. 2014 Jul;69(7):661-8. doi: 10.1016/j.crad.2014.01.003. Epub 2014 Feb 28. Link to article on publisher's site

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