2020 UMass Medical School Research Retreat

25th Annual UMMS Research Retreat

Monday, October 26, 2020 - Tuesday, October 27, 2020

Virtual event

The Graduate School of Biomedical Sciences and the UMass Center for Clinical and Translational Science thank you for a great 25th Annual University of Massachusetts Medical School (UMMS) Research Retreat! The research retreat highlights the medical school's vibrant scientific environment and ongoing research. This website features a collection of selected posters and presentations contributed by UMMS researchers.

Questions? Contact Heather Smith at Heather.Smith2@umassmed.edu.

Program and Materials
2020
Monday, October 26th
9:00 AM

Agenda: 2020 University of Massachusetts Medical School Research Retreat

UMMS Research Retreat

9:00 AM

Agenda for the 2020 virtual University of Massachusetts Medical School Research Retreat.

Welcome and Opening Remarks

Terence R. Flotte, University of Massachusetts Medical School
Michael F. Collins, University of Massachusetts Medical School
Katherine Luzuriaga, University of Massachusetts Medical School

9:00 AM

Welcome and Opening Remarks by:

Dr. Terence R. Flotte, Celia and Isaac Haidak Professor of Medical Education; Dean, Provost and Executive Deputy Chancellor and Chief Research Officer

Dr. Michael F. Collins, Chancellor and Professor, Population and Quantitative Health Sciences and Medicine; Senior Vice President for the Health Sciences

Dr. Katherine Luzuriaga, Professor, Molecular Medicine, Pediatrics, and Medicine; Director, UMass Center for Clinical and Translational Science; Vice Provost, Clinical and Translational Research

9:20 AM

New Faculty Talks

Roger J. Davis, University of Massachusetts Medical School
TengTing Lim, University of Massachusetts Medical School
William Flavahan, University of Massachusetts Medical School
Marcus Ruscetti, University of Massachusetts Medical School

9:20 AM

Moderator: Dr. Roger Davis, Chair and Professor in Molecular Medicine

Presenters:

Dr. TengTing (Elaine) Lim, Assistant Professor, Program in Bioinformatics and Integrative Biology and Molecular, Cell and Cancer Biology: “Multiplexing and demultiplexing with cerebral organoids for neurological diseases”

Dr. William Flavahan, Assistant Professor, Molecular, Cell and Cancer Biology: “Insulator dysfunction and epigenetic alterations as tumor drivers"

Dr. Marcus Ruscetti, Assistant Professor, Molecular, Cell and Cancer Biology: "Harnessing cellular senescence for cancer immunotherapy

10:40 AM

New Faculty Talks

Albertha J. M. Walhout, University of Massachusetts Medical School
Travis Thomson, University of Massachusetts Medical School
Rigel Chan, University of Massachusetts Medical School
Milena Bogunovic, University of Massachusetts Medical School

10:40 AM

Moderator: Dr. Marian Walhout, Professor, Program in Molecular Medicine and Co-Director, Program in Systems Biology

Presenters:

Dr. Travis Thomson, Assistant Professor, Neurobiology: “All hail our viral overloads - Traversing synaptic plasticity with transposons”

Dr. Rigel Chan, Assistant Professor, Neurology: “Multiplex pooled in-vitro modeling for genetic studies”

Dr. Milena Bogunovic, Associate Professor, Pathology: “Heterogeneity and function of intestinal macrophages"

1:00 PM

Poster Sessions: 2020 University of Massachusetts Medical School Research Retreat

UMMS Research Retreat

1:00 PM

List of poster session presentations for the 2020 virtual University of Massachusetts Medical School Research Retreat.

Virtual Poster Session #1

UMMS Research Retreat

1:00 PM

Virtual Poster Session #1 (see Poster Session agenda for presenter details) for the University of Massachusetts Medical School Graduate School of Biomedical Sciences 25th Annual Research Retreat, held online on October 26-27, 2020.

Full-text posters made available by presenters in this session:

Poster 12: "Supporting Family Members of Youth in Mental Health Crisis," Joshua Feriante, Maite Cintron, Ariella Shayani, Brian Denietolis, Emily Lauer, David M. Cochran, Yael Dvir, and Emily Rubin

Poster 22: "Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae," Kotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard E. Baker, and Allan S. Jacobson

2:05 PM

Student Talks

Kendall L. Knight, University of Massachusetts Medical School
Maureen M. Hester, University of Massachusetts Medical School
Xue Li, University of Massachusetts Medical School
Nicholas P. Rice, University of Massachusetts Medical School

2:05 PM

Moderator: Dr. Kendall L. Knight, Associate Dean, Graduate School of Biomedical Sciences and Professor, Biochemistry and Molecular Pharmacology

Presenters:

Maureen Hester, Division of Infectious Disease and Immunology (Stu Levitz lab): “Antigen specificity and cross reactivity in vaccine-mediated protection against cryptococcosis”

Xue Li, Bioinformatics and Integrative Biology (Elinor Karlsson lab): “Investigating the genetics of social behavior in wolf-dog hybrids”

Nicholas Rice, Program in Molecular Medicine (Bill Theurkauf lab): “Heat stress disrupts piRNA biogenesis machinery”

3:10 PM

Post-Doc Talks

Mary Ellen Lane, University of Massachusetts Medical School
Sneha Shah, University of Massachusetts Medical School
Emmanouela Tsagkaraki, University of Massachusetts Medical School
Khursheed A. Wani, University of Massachusetts Medical School

3:10 PM

Moderator: Dr. Mary Ellen Lane, Dean, Graduate School of Biomedical Sciences and Professor, Neurobiology

Presenters:

Sneha Shah, Program in Molecular Medicine (Joel Richter lab): “FMRP loss alters the epigenetic landscape and alternative splicing of mRNAs in Fragile X Syndrome”

Emmanouela Tsagkaraki, Program in Molecular Medicine (Mike Czech lab): “CRISPR RNP-enhanced adipocyte 'browning' as cell therapy for metabolic disease”

Khursheed Wani, Laboratory of Comparative Immunology (Javier Irazoqui lab): “NHR-49/PAARα and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

4:30 PM

Virtual Poster Session #2

UMMS Research Retreat

4:30 PM

Virtual Poster Session #2 (see Poster Session agenda for presenter details) for the University of Massachusetts Medical School Graduate School of Biomedical Sciences 25th Annual Research Retreat, held online on October 26-27, 2020.

Full-text posters made available by presenters in this session:

Poster 27: "Frailty Index Scores are Stronger Predictors of Complications in Free Flap Breast Reconstruction than BMI, Age, and ASA Class: A Retrospective Analysis on the ACS National Surgical Quality Improvement Program from 2010 - 2018," Alex Joo and Giorgio Giatsidis

Poster 29: "A ThinPrep Cytopathology of Cutaneous Meningioma with Histologic Correlation," Ahmed M. Alhusseiny and Rukmini M. Kashikar

Poster 35: "Targeted multielectrode tDCS increases functional connectivity within the arcuate fasciculus network: An exploratory study and analysis," Karl D. Lerud, Anant B. Shinde, Axel Thielscher, David A. Ross, and Gottfried Schlaug

Poster 42: "Transcranial Direct Current Stimulation for Post-stroke Motor Recovery - a Phase II Study (TRANSPORT2)," Muhammed E. Gunduz, Anant B. Shinde, Karl D. Lerud, Wayne Feng, and Gottfried Schlaug

Poster 49: "PAD2 Dysregulation and Abnormal Protein Citrullination in ALS Disease Models," Issa Yusuf, Tao Qiao, Ronak Tilvawala, Paul R. Thompson, and Zuoshang Xu

5:30 PM

Virtual Poster Session #3

UMMS Research Retreat

5:30 PM

Virtual Poster Session #3 (see Poster Session agenda for presenter details) for the University of Massachusetts Medical School Graduate School of Biomedical Sciences 25th Annual Research Retreat, held online on October 26-27, 2020.

Full-text posters made available by presenters in this session:

Poster 75: "PFN1 phosphorylation marks protein aggregation and white matter pathology in ALS," Sepideh Parsi, Tao Qiao, Lyle Wilfred Ostrow, Marco B. Rust, and Zuoshang Xu

Tuesday, October 27th
8:45 AM

Presentation: The Dan Mullen Awards for Best Posters

Kendall L. Knight, University of Massachusetts Medical School
Mary Ellen Lane, University of Massachusetts Medical School

8:45 AM

The Dan Mullen Poster Awards to best graduate student posters at the research retreat, presented by:

Dr. Kendall L. Knight, Associate Dean, Graduate School of Biomedical Sciences

Dr. Mary Ellen Lane, Dean, Graduate School of Biomedical Sciences

2020 Dan Mullen Poster Award winners:

Emily Agnello (Brian Kelch lab) – “Investigating the Self Assembly and Structural Features of a Thermophilic Bacteriophage”

Hao-Ching Jiang (Paul Greer lab) – “Analyzing the Role of MS4A1 in Olfaction”

Christine Carbone (Andrei Korostelev lab) – “Time-resolved Cryo-EM Visualizes Ribosomal Translocation with EF-G and GTP”

Naema Nayyar (Michael Brehm lab) – “Intracranial Responses to Immune Checkpoint Inhibitors in Pre-clinical Models of Melanoma Brain Metastasis”

9:00 AM

New Faculty Talks

Beth A. McCormick, University of Massachusetts Medical School
Hyun Youk, University of Massachusetts Medical School
Vanni Bucci, University of Massachusetts Medical School
James B. Munro, University of Massachusetts Medical School
Elizabeth A. Shank, University of Massachusetts Medical School

9:00 AM

Moderator: Dr. Beth McCormick, Vice Chair and Professor, Microbiology and Physiological Systems

Presenters:

Dr. Hyun Youk, Associate Professor, Program in Systems Biology: “Quantitative approach to understanding autonomous and collective deaths of microbial and mammalian cells”

Dr. Vanni Bucci, Associate Professor, Microbiology and Physiological Systems: “Machine learning to decouple associations between microbiome, host immunology and clinical outcome”

Dr. James Munro, Associate Professor, Microbiology and Physiological Systems: “Single-molecule analysis of HIV-1 genomic RNA conformation and dynamics”

Dr. Elizabeth Shank, Associate Professor, Program in Systems Biology and Microbiology and Physiological Systems: "Metabolic interactions in microbial communities"

10:45 AM

New Faculty Talks

Michael R. Green, University of Massachusetts Medical School
Johanna M. Seddon, University of Massachusetts Medical School
Sohye Kim, University of Massachusetts Medical School
Andres Colubri, University of Massachusetts Medical School

10:45 AM

Moderator: Dr. Michael Green, Chair and Professor, Molecular, Cell and Cancer Biology

Presenters:

Dr. Johanna Seddon, Professor, Ophthalmology and Visual Sciences: “Macular Degeneration epidemiology: nature-nurture, lifestyle factors, genetic risk, and gene-environment interactions: clues to therapies”

Dr. Sohye Kim, Assistant Professor, Psychiatry: “Neural markers of social engagement in the first year of life”

Dr. Andres Colubri, Assistant Professor, Microbiology and Physiological Systems: "ORAN: A meta-modeling platform to drive real-life and online outbreak simulations"

11:50 AM

COVID-19 Research

Thoru Pederson, University of Massachusetts Medical School
Robert W. Finberg, University of Massachusetts Medical School
Celia A. Schiffer, University of Massachusetts Medical School
Anastasia Khvorova, University of Massachusetts Medical School

11:50 AM

Moderator: Dr. Thoru Pederson, Professor, Biochemistry and Molecular Pharmacology and Associate Vice Provost for Research

Presenters:

Dr. Robert Finberg, Chair and Professor, Medicine: “SARS-CoV-2 and Influenza-What's the difference and why do I care?"

Dr. Celia Schiffer, Professor, Biochemistry and Molecular Pharmacology: "Structural insights to antivirals against SARS-CoV-2”

Dr. Anastasia Khvorova, Professor, RNA Therapeutics Institute: “Developing RNAi-based therapeutics for COVID-19 in five months”

12:55 PM

Closing Remarks

Terence R. Flotte, University of Massachusetts Medical School

12:55 PM

Closing Remarks by:

Dr. Terence R. Flotte, Celia and Isaac Haidak Professor of Medical Education; Dean, Provost and Executive Deputy Chancellor and Chief Research Officer