Myeloperoxidase in human intracranial aneurysms: preliminary evidence
Department of Radiology
Adult; Aged; Aneurysm, Ruptured; Biological Markers; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Models, Statistical; Peroxidase; Pilot Projects; Risk; Time Factors
Cardiovascular Diseases | Diagnosis | Nervous System Diseases | Radiology | Therapeutics
BACKGROUND AND PURPOSE: Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue. METHODS: Human brain aneurysms were harvested after clipping and were histologically and biochemically evaluated for the presence of myeloperoxidase. Of the tissue collected, 3 were from ruptured aneurysms and 20 were from UIAs. For each UIA, its 5-year aneurysm rupture risk was determined using the Population, Hypertension, Age, Size of Aneurysm, Earlier Subarachnoid Hemorrhage From Another Aneurysm and Site of Aneurysm (PHASES) model. RESULTS: All ruptured aneurysms were myeloperoxidase positive. Of the UIAs, half were myeloperoxidase positive. The median 5-year aneurysm rupture risk was higher for myeloperoxidase-positive UIA (2.28%) than myeloperoxidase-negative UIA (0.69%), and the distributions were statistically different (P<0.005, Wilcoxon-Mann-Whitney test). The likelihood for myeloperoxidase-positive UIA was significantly associated (P=0.031) with aneurysm rupture risk (odds ratio, 4.79; 95% confidence limits, 1.15-19.96). CONCLUSIONS: Myeloperoxidase is associated with PHASES estimated risk of aneurysm rupture and may potentially be used as an imaging biomarker of aneurysm instability.
DOI of Published Version
Stroke. 2014 May;45(5):1474-7. doi: 10.1161/STROKEAHA.114.004956. Epub 2014 Apr 8. Link to article on publisher's site
Stroke; a journal of cerebral circulation
Gounis, Matthew J.; Vedantham, Srinivasan; Weaver, John P.; Puri, Ajit S.; Brooks, Christopher S.; Wakhloo, Ajay K.; and Bogdanov, Alexei A. Jr., "Myeloperoxidase in human intracranial aneurysms: preliminary evidence" (2014). Radiology Publications and Presentations. 95.