Optical Coherence Tomography for Neurovascular Disorders
Department of Radiology
Cardiovascular Diseases | Nervous System Diseases | Radiology
Diagnosis of cerebrovascular disease includes vascular neuroimaging techniques such as computed tomography (CT) angiography, magnetic resonance (MR) angiography (with or without use of contrast agents) and catheter digital subtraction angiography (DSA). These techniques provide mostly information about the vessel lumen. Vessel wall imaging with MR seeks to characterize cerebrovascular pathology, but with resolution that is often insufficient for small lesions. Intravascular imaging techniques such as ultrasound and optical coherence tomography (OCT), used for over a decade in the peripheral circulation, is not amendable to routine deployment in the intracranial circulation due to vessel caliber and tortuosity. However, advances in OCT technology including the probe profile, stiffness and unique distal rotation solution, holds the promise for eventual translation of OCT into the clinical arena. As such, it is apropos to review this technology and present the rationale for utilization of OCT in the cerebrovasculature.
angiography, cerebrovascular disease, intracranial aneurysm, intracranial atherosclerosis, optical coherence tomography
DOI of Published Version
Anagnostakou V, Ughi GJ, Puri AS, Gounis MJ. Optical Coherence Tomography for Neurovascular Disorders. Neuroscience. 2021 Jun 12:S0306-4522(21)00300-6. doi: 10.1016/j.neuroscience.2021.06.008. Epub ahead of print. PMID: 34126186. Link to article on publisher's site
Anagnostakou V, Ughi GJ, Puri AS, Gounis MJ. (2021). Optical Coherence Tomography for Neurovascular Disorders. Radiology Publications. https://doi.org/10.1016/j.neuroscience.2021.06.008. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/644