Title
Left Ventricular Noncompaction Cardiomyopathy as a Potential Cause of Bilateral Posterior Cerebral Artery Stroke - a Rare and Unique Clinical Occurrence
UMMS Affiliation
Department of Neurology; Department of Medicine, Division of Cardiovascular Medicine; Department of Radiology, Division of Neuroimaging and Intervention
Publication Date
2021-06-22
Document Type
Article
Disciplines
Cardiovascular Diseases | Nervous System Diseases | Neurology
Abstract
BACKGROUND Bilateral posterior cerebral artery (PCA) occlusions are exceedingly rare, and are considered a devastating phenomenon that presents as cortical blindness. Predominant causes of PCA infarcts include cardiac and arterial embolisms. Left ventricular noncompaction (LVNC) cardiomyopathy is also an extremely rare cardiopathology. Several reports describe stroke as a potential manifestation of LVNC, but bilateral PCA infarcts are likely also caused by underlying LVNC cardiomyopathy, although this has not yet been reported.
CASE REPORT A 63-year-old man presented to the emergency department of an outside hospital with acute vision loss in both eyes and dysarthria. His neurological examination necessitated an emergent stroke evaluation. His electrocardiogram and telemetry at admission did not reveal arrhythmia. He underwent an emergency endovascular thrombectomy at our facility. During the post-intervention stroke workup, a transthoracic echocardiogram with contrast showed left ventricle dilation, with an ejection fraction (EF) of 29%. Subsequent cardiac magnetic resonance imaging confirmed the presence of LVNC cardiomyopathy. He was started on therapeutic anticoagulation (apixaban) and remained stable neurologically during the 3-month followup, with some residual visual field deficits. His cardiac outcome also improved (stress test was unremarkable for any cardiac ischemia, and an echocardiogram showing improved EF of 40%).
CONCLUSIONS Our report is distinct, as it presents 2 exceedingly rare events in a patient: the occurrence of simultaneous bilateral PCA infarcts and LVNC cardiomyopathy. Prompt and accurate diagnosis was pivotal to the successful management of both conditions. Prospective studies are warranted to further knowledge of LVNC pathophysiology and the occurrence of stroke in such patients so that comprehensive management plans can be devised.
Keywords
Cardiomyopathies, Infarction, Posterior Cerebral Artery, Stroke
Rights and Permissions
Copyright © Am J Case Rep, 2021. This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
DOI of Published Version
10.12659/AJCR.931103
Source
Elnazeir M, Nobel L, Narayanan S, Darmoch F, Massari F, Fitzgibbons T, Carandang RA, Jun-O'Connell A. Left Ventricular Noncompaction Cardiomyopathy as a Potential Cause of Bilateral Posterior Cerebral Artery Stroke - a Rare and Unique Clinical Occurrence. Am J Case Rep. 2021 Jun 22;22:e931103. doi: 10.12659/AJCR.931103. PMID: 34157014; PMCID: PMC8235723. Link to article on publisher's site
Journal/Book/Conference Title
The American journal of case reports
Related Resources
PubMed ID
34157014
Repository Citation
Elnazeir M, Nobel L, Narayanan S, Darmoch F, Massari F, Fitzgibbons TP, Carandang RA, Jun-O'Connell AH. (2021). Left Ventricular Noncompaction Cardiomyopathy as a Potential Cause of Bilateral Posterior Cerebral Artery Stroke - a Rare and Unique Clinical Occurrence. Radiology Publications. https://doi.org/10.12659/AJCR.931103. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/639
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.