UMMS Affiliation

Department of Pediatrics, Division of Pediatric Neonatalogy; Department of Radiology

Publication Date


Document Type



Maternal and Child Health | Pediatrics | Radiology


Very preterm infants are at risk for germinal matrix hemorrhage- intraventricular hemorrhage (GH-IVH). Severe GH-IVH may cause death or severe neurodevelopmental disability while mild GH-IVH is considered a static, non-progressive disease. This retrospective study aimed to determine if infants with no GH-IVH or mild GH-IVH on initial screening head ultrasound (HUS) advanced to severe GH-IVH. A total of 353 eligible infants with birth gestational age < /=32 0/7 weeks who received a HUS during hospitalization were identified. Of the 343 (97%) infants who had mild GH-IVH (grade II or less) on initial screening, only 4 (1.2%) progressed to severe (grade III or IV). Each of these infants required mechanical ventilation for at least 40 days. Therefore, premature infants who have no GH-IVH or mild GH-IVH on initial routine screening HUS without other risk factors may not require follow-up HUSs. Infants with prolonged mechanical ventilation may require further screening despite reassuring initial HUS findings.


head ultrasound, intraventricular hemorrhage, preterm birth

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Copyright © The Author(s) 2021. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (

DOI of Published Version



Daigneault J, White H, Dube A, Shi Q, Gauguet JM, Rhein L. Lack of Progression of Intraventricular Hemorrhage in Premature Infants: Implications for Head Ultrasound Screening. Glob Pediatr Health. 2021 May 19;8:2333794X211010729. doi: 10.1177/2333794X211010729. PMID: 34046517; PMCID: PMC8138291. Link to article on publisher's site

Journal/Book/Conference Title

Global pediatric health

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PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License