Title
Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist
UMMS Affiliation
Department of Radiology
Publication Date
2020-07-01
Document Type
Article
Disciplines
Radiology
Abstract
Immune checkpoint inhibitors are monoclonal antibodies directed against cellular pathways on T-cells to treat different types of malignancies. This new therapy can cause immune-related adverse events that can involve almost any organ system. This article will review clinical presentations, molecular mechanisms and imaging manifestations of adverse events caused by checkpoint inhibitors and also illustrate the pseudoprogression tumor response pattern.
Keywords
Checkpoint inhibitors, Immune-related adverse events, Immunotherapy, Pseudoprogression
DOI of Published Version
10.1016/j.clinimag.2020.02.006
Source
Furtado VF, Melamud K, Hassan K, Rohatgi S, Buch K. Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist. Clin Imaging. 2020 Jul;63:35-49. doi: 10.1016/j.clinimag.2020.02.006. Epub 2020 Feb 22. PMID: 32120311. Link to article on publisher's site
Journal/Book/Conference Title
Clinical imaging
Related Resources
PubMed ID
32120311
Repository Citation
Furtado VF, Melamud K, Hassan K, Rohatgi S, Buch K. (2020). Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist. Radiology Publications. https://doi.org/10.1016/j.clinimag.2020.02.006. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/595