Title

Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist

UMMS Affiliation

Department of Radiology

Publication Date

2020-07-01

Document Type

Article

Disciplines

Radiology

Abstract

Immune checkpoint inhibitors are monoclonal antibodies directed against cellular pathways on T-cells to treat different types of malignancies. This new therapy can cause immune-related adverse events that can involve almost any organ system. This article will review clinical presentations, molecular mechanisms and imaging manifestations of adverse events caused by checkpoint inhibitors and also illustrate the pseudoprogression tumor response pattern.

Keywords

Checkpoint inhibitors, Immune-related adverse events, Immunotherapy, Pseudoprogression

DOI of Published Version

10.1016/j.clinimag.2020.02.006

Source

Furtado VF, Melamud K, Hassan K, Rohatgi S, Buch K. Imaging manifestations of immune-related adverse effects in checkpoint inhibitor therapies: A primer for the radiologist. Clin Imaging. 2020 Jul;63:35-49. doi: 10.1016/j.clinimag.2020.02.006. Epub 2020 Feb 22. PMID: 32120311. Link to article on publisher's site

Journal/Book/Conference Title

Clinical imaging

Related Resources

Link to Article in PubMed

PubMed ID

32120311

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