Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives

UMMS Affiliation

Department of Pathology; Department of Radiology

Publication Date


Document Type



Male Urogenital Diseases | Neoplasms | Pathology | Radiology | Urology


Intraductal carcinoma of the prostate (IDC-P), a clinicopathological entity characterized by malignant prostatic epithelial cells growing within ducts and/or acini, has a distinct architectural pattern, cytological features, and biological behavior. Whereas most IDC-P tumors could be derived from adjacent high-grade invasive cancer via retrograde spreading of cancer cells along benign ducts and acini, a small subset of IDC-P may arise from the transformation and intraductal proliferation of precancerous cells induced by various oncogenic events. These isolated IDC-P tumors possess a distinct mutational profile and may function as a carcinoma in situ lesion with de novo intraductal outgrowth of malignant cells. Further molecular characterization of these two types of IDC-P and better understanding of the mechanisms underlying IDC-P formation and progression could be translated into valuable biomarkers for differential diagnosis and actionable targets for therapeutic interventions.

PATIENT SUMMARY: Intraductal carcinoma of the prostate is an aggressive type of prostate cancer associated with high risk for local recurrence and distant metastasis. In this review, we discussed pathogenesis, biomarkers, differential diagnoses, and therapeutic strategies for this tumor.


Differential diagnosis, Germline DNA repair gene, Gleason grading, Intraductal carcinoma of the prostate, Molecular genetics, Prostate

DOI of Published Version



Zong Y, Montironi R, Massari F, Jiang Z, Lopez-Beltran A, Wheeler TM, Scarpelli M, Santoni M, Cimadamore A, Cheng L. Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives. Eur Urol Focus. 2020 Oct 29:S2405-4569(20)30291-1. doi: 10.1016/j.euf.2020.10.007. Epub ahead of print. PMID: 33132109. Link to article on publisher's site

Journal/Book/Conference Title

European urology focus

Related Resources

Link to Article in PubMed

PubMed ID