New England Center for Stroke Research; Department of Radiology
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Cardiovascular Diseases | Nervous System | Nervous System Diseases | Radiology
Intravascular imaging has emerged as a valuable tool for the treatment of coronary and peripheral artery disease; however, no solution is available for safe and reliable use in the tortuous vascular anatomy of the brain. Endovascular treatment of stroke is delivered under image guidance with insufficient resolution to adequately assess underlying arterial pathology and therapeutic devices. High-resolution imaging, enabling surgeons to visualize cerebral arteries' microstructure and micron-level features of neurovascular devices, would have a profound impact in the research, diagnosis, and treatment of cerebrovascular diseases. Here, we present a neurovascular high-frequency optical coherence tomography (HF-OCT) system, including an imaging console and an endoscopic probe designed to rapidly acquire volumetric microscopy data at a resolution approaching 10 microns in tortuous cerebrovascular anatomies. Using a combination of in vitro, ex vivo, and in vivo models, the feasibility of HF-OCT for cerebrovascular imaging was demonstrated.
Microendoscopy, Brain, Medical imaging, Neurological disorders, Imaging and sensing
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DOI of Published Version
Ughi GJ, Marosfoi MG, King RM, Caroff J, Peterson LM, Duncan BH, Langan ET, Collins A, Leporati A, Rousselle S, Lopes DK, Gounis MJ, Puri AS. A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy. Nat Commun. 2020 Jul 31;11(1):3851. doi: 10.1038/s41467-020-17702-7. PMID: 32737314; PMCID: PMC7395105. Link to article on publisher's site
Ughi GJ, Marosfoi MG, King RM, Caroff J, Peterson LM, Duncan BH, Langan ET, Collins AJ, Leporati AM, Rousselle S, Lopes DK, Gounis MJ, Puri AS. (2020). A neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy. Radiology Publications. https://doi.org/10.1038/s41467-020-17702-7. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/553
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This work is licensed under a Creative Commons Attribution 4.0 License.
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