Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
Department of Radiology
Chemical Actions and Uses | Chemistry | Enzymes and Coenzymes | Radiology | Respiratory Tract Diseases
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
5-hydroxytryptamide, MRI, contrast agent, gadolinium, pulmonary fibrosis
DOI of Published Version
ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site
Rodriguez-Rodriguez, Aurora; Shuvaev, Sergey; Rotile, Nicholas; Jones, Chloe M.; Probst, Clemens K.; Dos Santos Ferreira, Diego; Graham-O Regan, Katherine; Boros, Eszter; Knipe, Rachel S.; Griffith, Jason W.; Tager, Andrew M.; Bogdanov, Alexei A. Jr.; and Caravan, Peter, "Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation" (2019). Radiology Publications and Presentations. 493.