Title
Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
UMMS Affiliation
Department of Radiology
Publication Date
2019-08-09
Document Type
Article
Disciplines
Chemical Actions and Uses | Chemistry | Enzymes and Coenzymes | Radiology | Respiratory Tract Diseases
Abstract
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
Keywords
5-hydroxytryptamide, MRI, contrast agent, gadolinium, pulmonary fibrosis
DOI of Published Version
10.1021/acssensors.9b01010
Source
ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site
Journal/Book/Conference Title
ACS sensors
Related Resources
PubMed ID
31397156
Repository Citation
Rodriguez-Rodriguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov AA, Caravan P. (2019). Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. Radiology Publications and Presentations. https://doi.org/10.1021/acssensors.9b01010. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/493