Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
Department of Radiology
Chemical Actions and Uses | Chemistry | Enzymes and Coenzymes | Radiology | Respiratory Tract Diseases
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
5-hydroxytryptamide, MRI, contrast agent, gadolinium, pulmonary fibrosis
DOI of Published Version
ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site
Rodriguez-Rodriguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov AA, Caravan P. (2019). Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. Radiology Publications. https://doi.org/10.1021/acssensors.9b01010. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/493