Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
Department of Radiology
Chemical Actions and Uses | Chemistry | Enzymes and Coenzymes | Radiology | Respiratory Tract Diseases
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
5-hydroxytryptamide, MRI, contrast agent, gadolinium, pulmonary fibrosis
DOI of Published Version
ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site
Rodriguez-Rodriguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov AA, Caravan P. (2019). Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation. Radiology Publications and Presentations. https://doi.org/10.1021/acssensors.9b01010. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/493