Title

Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

UMMS Affiliation

Department of Radiology

Publication Date

2019-08-09

Document Type

Article

Disciplines

Chemical Actions and Uses | Chemistry | Enzymes and Coenzymes | Radiology | Respiratory Tract Diseases

Abstract

An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.

Keywords

5-hydroxytryptamide, MRI, contrast agent, gadolinium, pulmonary fibrosis

DOI of Published Version

10.1021/acssensors.9b01010

Source

ACS Sens. 2019 Aug 22. doi: 10.1021/acssensors.9b01010. [Epub ahead of print] Link to article on publisher's site

Journal/Book/Conference Title

ACS sensors

Related Resources

Link to Article in PubMed

PubMed ID

31397156

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