Division of Cell Biology and Imaging, Department of Radiology; Luna Lab
Amino Acids, Peptides, and Proteins | Biochemistry | Cell Biology | Cells | Cellular and Molecular Physiology | Developmental Biology | Musculoskeletal System
"Myosin" is famous as a component of muscle fibrils, but the majority of myosin family members act elsewhere with roles unrelated to muscle contraction. The biological functions of a relatively new family of these unconventional myosins, myosins 18A and 18B, are poorly understood. New research from Horsthemke et al. describes a new isoform (Myo18Agamma) that is essential for heart function and viability in mice. Their findings both support and contradict other work in the field and raise new questions about the roles of myosin 18 proteins in vivo.
myosin, myosin 18A, myosin 18B, muscle
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© 2019 Luna. Publisher's PDF posted after 12 months as allowed by the publisher's author rights policy at http://www.jbc.org/site/misc/edpolicy.xhtml#copyright.
DOI of Published Version
This research was originally published in: J Biol Chem. 2019 May 3;294(18):7219-7220. doi: 10.1074/jbc.H119.008784. Link to article on publisher's site
The Journal of biological chemistry
Luna EJ. (2019). Unconventional myosins muscle into myofibrils. Radiology Publications. https://doi.org/10.1074/jbc.H119.008784. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/470
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