Title
Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations
UMMS Affiliation
Department of Radiology, New England Center for Stroke Research
Publication Date
2019-02-07
Document Type
Article
Disciplines
Animal Experimentation and Research | Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology
Abstract
Neuroendovascular procedures have led to breakthroughs in the treatment of ischemic stroke, intracranial aneurysms, and intracranial arteriovenous malformations. Due to these substantial successes, there is continuous development of novel and refined therapeutic approaches. Large animal models feature various conceptual advantages in translational research, which makes them appealing for the development of novel endovascular treatments. However, the availability and role of large animal models have not been systematically described so far. Based on comprehensive research in two databases, this systematic review describes current large animal models in neuroendovascular research including their primary use. It may therefore serve as a compact compendium for researchers entering the field or looking for opportunities to refine study concepts. It also describes particular applications for ischemic stroke and aneurysm therapy, as well as for the treatment of arteriovenous malformations. It focuses on most promising study designs and readout parameters, as well as on important pitfalls in endovascular translational research including ways to circumvent them.
Keywords
Endovascular, aneurysm, arteriovenous malformations, large animal models, stroke
DOI of Published Version
10.1177/0271678X19827446
Source
J Cereb Blood Flow Metab. 2019 Mar;39(3):375-394. doi: 10.1177/0271678X19827446. Epub 2019 Feb 7. Link to article on publisher's site
Journal/Book/Conference Title
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Related Resources
PubMed ID
30732549
Repository Citation
Herrmann, Andrea M.; Meckel, Stephan; Gounis, Matthew J.; Kringe, Leona; Motschall, Edith; Mulling, Christoph; and Boltze, Johannes, "Large animals in neurointerventional research: A systematic review on models, techniques and their application in endovascular procedures for stroke, aneurysms and vascular malformations" (2019). Radiology Publications and Presentations. 447.
https://escholarship.umassmed.edu/radiology_pubs/447