Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT
Department of Radiology
Cardiology | Radiology
BACKGROUND: We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function.
METHODS: We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 +/- 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we considered both filtered backprojection (FBP) without correction for degradations, and iterative ordered-subsets expectation-maximization (OS-EM) with resolution, attenuation and scatter corrections.
RESULTS: With dose level lowered to 25% of full dose, the obtained results on motion/thickening, EF and abnormal motion detection were statistically comparable to full dose in both reconstruction strategies, with Pearson's r > 0.9 for global motion measures between low dose and full dose.
CONCLUSIONS: The administered activity could be reduced to 25% of full dose without degrading the function assessment performance. Low dose reconstruction optimized for perfusion-defect detection can be reasonable for function assessment in gated SPECT.
CAD, MPI, SPECT, gated SPECT, image reconstruction
DOI of Published Version
J Nucl Cardiol. 2018 Nov 7. doi: 10.1007/s12350-018-01505-x. [Epub ahead of print] Link to article on publisher's site
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Juan Ramon, Albert; Yang, Yongyi; Wernick, Miles N.; Pretorius, P. Hendrik; Johnson, Karen L.; Slomka, Piotr J.; and King, Michael A., "Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT" (2018). Radiology Publications and Presentations. 434.