Title

Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model

Authors

Jacquelyn MacDonell, Albany Medical College
Matthew J. Gounis, University of Massachusetts Medical SchoolFollow
Robert M. King, University of Massachusetts Medical SchoolFollow
Gene Bogdanov, University of Massachusetts Medical School
Olivia W. Brooks, University of Massachusetts Medical SchoolFollow
Erin T. Langan, University of Massachusetts Medical SchoolFollow
Julie G. Pilitsis, Albany Medical College, New York

UMMS Affiliation

Department of Radiology; New England Center for Stroke Research

Publication Date

2018-06-14

Document Type

Article

Disciplines

Neurology | Radiology | Surgery

Abstract

BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS).

OBJECTIVE: To describe our experience with interstitial focused ultrasound (iFUS) ablations in swine, using MR-guided robotically assisted (MRgRA) delivery.

METHODS: In an initial 3 animals, we optimized the workflow of the robot in the MR suite and made modifications to the robotic arm to allow range of motion. Then, 6 farm pigs (4 acute, 2 survival) underwent 7 iMRgFUS ablations using MRgRA. We altered dosing to explore differences between thermal dosing in brain as compared to other tissues. Imaging was compared to gross examination.

RESULTS: Our work culminated in adjustments to the MRgRA, iMRgFUS probes, and dosing, culminating in 2 survival surgeries; swine had ablations with no neurological sequelae at 2 wk postprocedure. Immediately following iMRgFUS therapy, diffusion-weighted imaging, and T1 weighted MR were accurate reflections of the ablation volume. T2 and fluid-attenuated inversion-recovery (FLAIR) images were accurate reflections of ablation volume 1-wk postprocedure.

CONCLUSION: We successfully performed MRgRA iFUS ablation in swine and found intraoperative and postoperative imaging to correlate with histological examination. These data are useful to validate our system and to guide imaging follow-up for thermal ablation lesions in brain tissue from our therapy, tcMRgFUS, and LITT.

DOI of Published Version

10.1093/neuros/nyy266

Source

Neurosurgery. 2018 Jun 14. pii: 5037802. doi: 10.1093/neuros/nyy266. Link to article on publisher's site

Journal/Book/Conference Title

Neurosurgery

Comments

Full list of authors omitted for brevity. For full list see article.

Related Resources

Link to Article in PubMed

PubMed ID

29905844

Repository Citation

MacDonell J, Gounis MJ, King RM, Bogdanov G, Brooks OW, Langan ET, Pilitsis JG. (2018). Robotic Assisted MRI-Guided Interventional Interstitial MR Guided Focused Ultrasound Ablation in a Swine Model. Radiology Publications. https://doi.org/10.1093/neuros/nyy266. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/403