Title
Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
UMMS Affiliation
Department of Radiology, Division of Neuroimaging and Intervention; New England Center for Stroke Research
Publication Date
2017-02-08
Document Type
Article
Disciplines
Neurology | Radiology | Surgery
Abstract
BACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.
METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.
RESULTS: After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.
CONCLUSIONS: This model can be used to test the effects of FDs in future studies.
Keywords
Aneurysm, Artery, Flow Diverter, Technique
DOI of Published Version
10.1136/neurintsurg-2016-012878
Source
J Neurointerv Surg. 2017 Feb 8. pii: neurintsurg-2016-012878. 10.1136/neurintsurg-2016-012878. Link to article on publisher's site
Journal/Book/Conference Title
Journal of neurointerventional surgery
Related Resources
PubMed ID
28179543
Repository Citation
Aquarius R, Smits D, Gounis MJ, Leenders WP, de Vries J. (2017). Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study. Radiology Publications. https://doi.org/10.1136/neurintsurg-2016-012878. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/339