Department of Radiology; Department of Surgery; Department of Pathology
Hemic and Lymphatic Diseases | Radiology | Surgery
Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented with a palpable breast lump that was highly suspicious for malignancy based on mammogram and ultrasound appearance. Biopsy revealed inflammatory tissue with lymphoplasmacytic and histiocytic predominance. The diagnosis of Rosai-Dorfman was made based on characteristic staining of histiocytes with S-100 and the presence of emperipolesis. Early recognition of this benign disease entity spared the patient further investigation and surgical intervention.
breast, inflammatory disorder, non-malignant breast disease, rosai-dorfman, sinus histiocytosis with massive lymphadenopathy
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Copyright 2017 Delaney et al.
DOI of Published Version
Cureus. 2017 Apr 11;9(4):e1153. doi: 10.7759/cureus.1153. Link to article on publisher's site
Delaney, Eileen E.; Larkin, Anne C.; MacMaster, Sue; Sakhdari, Ali; and Debenedectis, Carolynn M., "Rosai-Dorfman Disease of the Breast" (2017). Radiology Publications and Presentations. 333.
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