UMMS Affiliation

Department of Radiology; Department of Surgery; Department of Pathology

Publication Date


Document Type



Hemic and Lymphatic Diseases | Radiology | Surgery


Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented with a palpable breast lump that was highly suspicious for malignancy based on mammogram and ultrasound appearance. Biopsy revealed inflammatory tissue with lymphoplasmacytic and histiocytic predominance. The diagnosis of Rosai-Dorfman was made based on characteristic staining of histiocytes with S-100 and the presence of emperipolesis. Early recognition of this benign disease entity spared the patient further investigation and surgical intervention.


breast, inflammatory disorder, non-malignant breast disease, rosai-dorfman, sinus histiocytosis with massive lymphadenopathy

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Copyright 2017 Delaney et al.

DOI of Published Version



Cureus. 2017 Apr 11;9(4):e1153. doi: 10.7759/cureus.1153. Link to article on publisher's site

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Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.



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