Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy
Department of Radiology
Cardiology | Radiology
BACKGROUND: We investigated the extent to which the administered dose (activity) level can be reduced without sacrificing diagnostic accuracy for three reconstruction strategies for SPECT-myocardial perfusion imaging (MPI).
METHODS: We optimized the parameters of the three reconstruction strategies for perfusion-defect detection over a range of simulated administered dose levels using a set of hybrid studies (derived from 190 subjects) consisting of clinical SPECT-MPI data modified to contain realistic simulated lesions. The optimized strategies we considered are filtered backprojection (FBP) with no correction for degradations, ordered-subsets expectation-maximization (OS-EM) with attenuation correction (AC), scatter correction (SC), and resolution correction (RC), and OS-EM with scatter and resolution correction only. Each study was evaluated using a total perfusion deficit (TPD) score computed by the Quantitative Perfusion SPECT (QPS) software package. We conducted a receiver operating characteristics (ROC) study based on the TPD scores for each dose level and reconstruction strategy.
RESULTS: For FBP, the achieved optimum values of the area under the ROC curve (AUC) at 100%, 50%, 25%, and 12.5% of standard dose were 0.75, 0.74, 0.72, and 0.70, respectively, compared to 0.81, 0.79, 0.76, and 0.74 for OS-EM with AC-SC-RC and 0.78, 0.77, 0.74, 0.72 for OS-EM with SC-RC.
CONCLUSIONS: Our results suggest that studies reconstructed by OS-EM with AC-SC-RC could possibly be reduced, on average, to 25% of the originally administered dose without causing diagnostic accuracy (AUC) to decrease below that of FBP.
Myocardial perfusion imaging, SPECT, dose reduction, optimization
DOI of Published Version
J Nucl Cardiol. 2017 May 23. doi: 10.1007/s12350-017-0920-1. Link to article on publisher's site
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Juan Ramon A, Yang Y, Pretorius PH, Slomka PJ, Johnson KL, King MA, Wernick MN. (2017). Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy. Radiology Publications. https://doi.org/10.1007/s12350-017-0920-1. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/317