Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study
Department of Radiology; New England Center for Stroke Research
Neurology | Radiology
BACKGROUND AND PURPOSE: Intracranial aneurysms treated by coiling have a risk for recurrence, requiring surveillance imaging. MRA has emerged as an attractive technique for postcoiling aneurysm imaging. Previous research has evaluated MR imaging artifacts of the coil mass in vitro. Our aim in this study was to evaluate MR imaging artifacts of coiled aneurysms in vivo with time.
MATERIALS AND METHODS: Four sidewall aneurysms were created in each of 4 dogs. Aneurysms were embolized receiving only 1 type of coils. After embolization, the animals were transferred to MR imaging, which included axial 3D TOF MRA (TEs, 3.5, 5, and 6.9 ms), phase-contrast MRA, and coronal CE-MRA. MR imaging studies were repeated at 1, 4, 6, 8, 14, and 28 weeks. We calculated an OEF: OEF = V(A)/V(CM), where the numerator represents the volume of the MR imaging artifacts and the denominator is the true volume of the coil mass measured by 3D RA.
RESULTS: OEFs were largest immediately after embolization and showed a gradual decay until approximately 4 weeks, when there was stabilization of the size of the artifacts. By 4 weeks, there was mild coil compaction (average coil mass volume decrease of 7.8%); however, the OEFs decreased by 25% after 4 weeks (P < .001).
CONCLUSIONS: MR imaging susceptibility artifacts change with time, being maximal in the postembolization setting and decaying until 4 weeks. The clinical implications of this study are that baseline MRA for comparison with future imaging should be acquired at a minimum of 1 week after the procedure.
DOI of Published Version
AJNR Am J Neuroradiol. 2012 Apr;33(4):655-60. Epub 2011 Dec 22. Link to article on publisher's site
AJNR. American journal of neuroradiology
Spilberg, Gabriela; Carniato, Sarena L.; King, R. M.; van der Bom, Imramsjah M. J.; Mehra, Manik; Walvick, Ronn P.; Wakhloo, Ajay K.; and Gounis, Matthew J., "Temporal evolution of susceptibility artifacts from coiled aneurysms on MR angiography: an in vivo canine study" (2012). Radiology Publications and Presentations. 303.