Title
Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration
UMMS Affiliation
Department of Medicine; Department of Pathology; Department of Radiology
Publication Date
2014-11-01
Document Type
Article
Disciplines
Pathology | Radiology | Surgery
Abstract
BACKGROUND: Ischemia-reperfusion injury (IRI) of the liver is a well-known cause of morbidity and mortality after liver transplantation. Effective treatment strategies aimed at decreasing hepatic IRI injury and accelerating liver regeneration could offer major benefits in liver transplantation, especially in the case of partial allografts. Human adipose-derived mesenchymal stem cells (HADMSCs) are an attractive source for regenerative medicine because of their anti-inflammatory and regenerative properties. We hypothesized that HADMSCs attenuate IRI and promote liver regeneration.
METHODS: Mice were subjected to 60 minutes of partial IRI with or without 70% partial hepatectomy. Animals were treated with HADMSCs. Liver IRI was evaluated with serum levels of alanine aminotransferase, serum interleukin-6, and histopathology. Liver samples were stained for specific markers of liver regeneration.
RESULTS: Histology, serum interleukin-6, and alanine aminotransferase release revealed that treatment with HADMSCs attenuated liver injury compared with control patients. Improved animal survival and increased number of regenerating cells were observed in HADMSC-treated animals who underwent IRI and partial hepatectomy compared with the control group.
CONCLUSION: HADMSC represents a potential therapeutic strategy to decrease IRI and promote regeneration in liver transplantation.
DOI of Published Version
10.1016/j.surg.2014.05.008
Source
Surgery. 2014 Nov;156(5):1225-31. Epub 2014 Sep26. Link to article on publisher's site
Journal/Book/Conference Title
Surgery
Related Resources
PubMed ID
25262218
Repository Citation
Saidi RF, Rajeshkumar BR, Shariftabrizi A, Bogdanov AA, Zheng S, Dresser KA, Walter O. (2014). Human adipose-derived mesenchymal stem cells attenuate liver ischemia-reperfusion injury and promote liver regeneration. Radiology Publications. https://doi.org/10.1016/j.surg.2014.05.008. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/264