Radiologic-Pathologic Discordance and Outcome After MRI-Guided Vacuum-Assisted Biopsy
Department of Radiology
Neoplasms | Oncology | Pathology | Radiology
OBJECTIVE: The purpose of this study was to determine the rate, characteristics, and outcomes of discordant MRI-guided vacuum-assisted biopsy (VAB) in women with suspected breast cancer.
MATERIALS AND METHODS: This retrospective study reviewed 1314 MRI-guided VABs performed in 1211 women between 2007 and 2013 and yielded 25 discordant results in 24 women. MRI characteristics; BI-RADS assessments; whether the lesion was missed, partially sampled, or excised at biopsy; and biopsy and surgical pathology results were reviewed. Statistical analyses were performed using Fisher exact and Mann-Whitney U tests.
RESULTS: Among 1314 lesions that underwent MRI-guided VAB, 25 results were discordant (1.9%; 95% CI, 1.2-2.8%), and nine lesions with discordant results (36.0%, 95% CI, 18.5-56.9%) were malignant at surgical excision (three invasive ductal carcinoma and six ductal carcinoma in situ). There was no significant association between malignancy and lesion type, size, enhancement pattern, BI-RADS assessment, or clinical indication. Forty-four percent (11/25) of discordant lesions were missed, 48.0% (12/25) were partially sampled, and 8.0% (2/25) appeared to have been excised. Of the nine malignant lesions, 44.4% (4/9) discordant malignant lesions were missed, 44.4% (4/9) were partially sampled, and 11.1% (1/9) appeared to have been excised. Lesion sizes and types were similar in the missed and partially excised groups.
CONCLUSION: The potential for false-negative results at MRI-guided VAB underscores the importance of radiologic-histologic correlation and imaging review after biopsy. Rebiopsy or excision in discordant cases is therefore recommended.
MRI, breast cancer, discordance, vacuum-assisted biopsy
DOI of Published Version
AJR Am J Roentgenol. 2017 Jan;208(1):W17-W22. Epub 2016 Oct 27. Link to article on publisher's site
AJR. American journal of roentgenology
Lewin, Alana A.; Heller, Samantha L.; Jaglan, Sonam; Elias, Kristin; Newburg, Adrienne; Melsaether, Amy; and Moy, Linda, "Radiologic-Pathologic Discordance and Outcome After MRI-Guided Vacuum-Assisted Biopsy" (2017). Radiology Publications and Presentations. 208.