Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm
Department of Radiology; Department of Radiation Oncology; Department of Surgery; Department of Medicine, Division of Gastroenterology
Digestive System Diseases | Gastroenterology | Hepatology | Neoplasms | Oncology | Radiology | Surgery
Purpose: Evaluate the recurrence pattern of hepatocellular carcinoma (HCC) following liver transplantation.
Materials and Methods: A total of 54 patients underwent liver transplantation for HCC; 9 patients developed biopsy proven recurrent HCC (16.6%). The site of HCC recurrence along with other factors were analyzed.
Results: Seven patients were diagnosed with HCC prior to liver transplantation and 2 patients had incidental HCC in the explanted liver. Two patients had locoregional recurrence, 4 patients had distant metastasis and 3 patients had synchronous locoregional recurrence and distant metastasis.
Conclusion: A significant proportion of HCC recurrence following liver transplantation is extrahepatic.
Hepatocellular carcinoma, HCC, Liver transplantation, surveillance, metastasis
DOI of Published Version
Scortegagna E Jr, Karam AR, Sioshansi S, Bozorgzadeh A, Barry C, Hussain S. Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm. Clin Imaging. 2016 Jul 7;40(6):1131-1134. doi: 10.1016/j.clinimag.2016.07.002. [Epub ahead of print] PubMed PMID: 27474913.
Scortegagna, Eduardo; Karam, Adib R.; Sioshansi, Shirin; Bozorgzadeh, Adel; Barry, Curtis T.; and Hussain, Sarwat, "Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm" (2016). Radiology Publications and Presentations. 179.