Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia
Department of Radiology
Cardiovascular Diseases | Radiology | Respiratory Tract Diseases
PURPOSE: In this study, a new model of pulmonary embolism in rats was developed and tested, to examine if hyperpolarized (HP) (3) He MR images can measure impairment of the exchange of oxygen from the airspaces to the blood during pulmonary embolism.
METHODS: HP (3) He MRI was used to image six treatment-group rats in which a branch of the pulmonary artery was embolized, and six control-group rats. HP (3) He MR images were used to calculate the initial partial pressure of oxygen (pO ) and the rate of oxygen depletion (R) in rat lungs.
RESULTS: The pO was significantly higher in the ischemic lung than in the contralateral normal side, and pO was significantly higher in the ischemic lung than in both sides of the control lungs. Mean R in ischemic lungs was significantly lower than in the contralateral lungs, and mean R in ischemic lungs was also significantly lower than in both control lungs.
CONCLUSION: These results demonstrate that pO and R, as measured by the T1 decay of HP (3) He, are sensitive to pulmonary ischemia in rats, confirming the findings in studies performed in large animal models of pulmonary ischemia.
Digital Subtraction Angiography, Hyperpolarized Helium, Pulmonary Embolism, Small Animal Imaging
DOI of Published Version
Magn Reson Med. 2016 May;75(5):2050-4. doi: 10.1002/mrm.25714. Epub 2015 Jun 16. Link to article on publisher's site
Magnetic resonance in medicine
Walvick, Ronn P.; Roche, John P.; Reno, Austin L.; Gounis, Matthew J.; and Albert, Mitchell S., "Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia" (2016). Radiology Publications and Presentations. 168.