Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography
Department of Radiology
Bioimaging and Biomedical Optics | Medical Biophysics | Optics | Radiology
Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 muM vs. 9.5 muM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.
Medical optics instrumentation, Imaging systems, Mammography
DOI of Published Version
Biomed Opt Express. 2015 Nov 19;6(12):4981-91. doi: 10.1364/BOE.6.004981. eCollection 2015. Link to article on publisher's site
Biomedical optics express
Michaelsen, Kelly E.; Krishnaswamy, Venkataramanan; Shi, Linxi; Vedantham, Srinivasan; Poplack, Steven P.; Karellas, Andrew; Pogue, Brian W.; and Paulsen, Keith D., "Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography" (2015). Radiology Publications and Presentations. 149.