Effect of needle gauge and lobe laterality on parenchymal liver biopsy outcome: a retrospective analysis
Department of Radiology
PURPOSE: To analyze the effect of lobe selection, needle gauge, and number of passes on procedure outcomes in terms of specimen length and post-procedure complications.
METHODS: In this HIPAA-compliant, IRB-approved retrospective study, the data from 771 ultrasound-guided adult parenchymal liver biopsies were analyzed. Post-procedure complications were assigned a 3-point rating scale. Associations between specimen length and post-procedure complications with lobe laterality, needle gauge, and number of passes were analyzed. Multivariate logistic regression models were used to analyze the likelihood for achieving a specimen length of at least 2 cm.
RESULTS: Post-procedure complications were not associated with lobe laterality, needle gauge, and number of passes (p > 0.3). Specimen length was associated with the number of passes dichotomized at the study mean (p = 0.007), but not with lobe laterality or needle gauge (p > 0.2). After adjusting for lobe laterality and needle gauge, procedures with 1 or 2 passes were associated with a higher likelihood of obtaining a 2 cm or longer specimen (OR 2.469; CI 1.08-5.63, p = 0.0315) than procedures with 3 or more passes, possibly due to poorer sample quality. After adjusting for lobe laterality, an 18-gauge needle was associated with higher odds of a biopsy procedure with 1 or 2 passes (OR 3.665; CI 1.93-6.95, p < 0.0001) than a 20-gauge needle.
CONCLUSIONS: Lobe laterality was not associated with specimen length or post-procedure complications. An 18-gauge needle compared to a 20-gauge needle could reduce the need for a procedure with more than 2 passes. There was no difference in post-procedure complications between the two needle sizes.
Liver, Image-guided biopsy, Ultrasonography, Hepatitis
DOI of Published Version
Abdom Imaging. 2014 Nov 4. Link to article on publisher's site.
Vijayaraghavan G, Vedantham S, Rangan V, Karam AR, Zheng L, Roychowdhury A, Hussain S. (2014). Effect of needle gauge and lobe laterality on parenchymal liver biopsy outcome: a retrospective analysis. Radiology Publications and Presentations. https://doi.org/10.1007/s00261-014-0290-y. Retrieved from https://escholarship.umassmed.edu/radiology_pubs/123