Department of Neurology; Department of Radiology
Immune System Diseases | Nervous System Diseases | Neurology | Radiology
OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis.
METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed.
RESULTS: The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well.
CONCLUSION: LGI1 antibody-associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.
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Copyright © 2014 American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
DOI of Published Version
Neurol Neuroimmunol Neuroinflamm. 2014 Dec 11;1(4):e51. doi: 10.1212/NXI.0000000000000051. eCollection 2014 Dec. Link to article on publisher's site
Neurology(R) neuroimmunology and neuroinflammation
Mayasi, Yunis M.; Takhtani, Deepak; and Garg, Neeta, "Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report" (2014). Radiology Publications and Presentations. 120.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.