UMMS Affiliation

Department of Neurology; Department of Radiology

Publication Date


Document Type



Immune System Diseases | Nervous System Diseases | Neurology | Radiology


OBJECTIVE: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis.

METHODS: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed.

RESULTS: The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well.

CONCLUSION: LGI1 antibody-associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.

Rights and Permissions

Copyright © 2014 American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.

DOI of Published Version



Neurol Neuroimmunol Neuroinflamm. 2014 Dec 11;1(4):e51. doi: 10.1212/NXI.0000000000000051. eCollection 2014 Dec. Link to article on publisher's site

Journal/Book/Conference Title

Neurology(R) neuroimmunology and neuroinflammation

Related Resources

Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.



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