Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics
Department of Radiology; New England Center for Stroke Research
Cardiovascular Diseases | Nanomedicine | Nervous System Diseases | Radiology | Therapeutics
Obstruction of normal blood flow, which occurs in a variety of diseases, including thromboembolism in stroke and atherosclerosis, is a leading cause of death and long-term adult disability in the Western world. This review focuses on a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels by high-fluid shear stresses to selectively target drugs to sites of vascular obstruction. In vitro and in vivo studies have shown that this approach can be used to efficiently lyse clots using a significantly lower amount of thrombolytic drug than is required when administered in a soluble formulation. This nanotherapeutic strategy can potentially improve both the efficacy and safety of thrombolytic drugs, particularly in patients who are at high risk for brain hemorrhage, and thus provide a new approach for the treatment of many life-threatening and debilitating vascular disorders.
DOI of Published Version
JAMA Neurol. 2015 Jan;72(1):119-22. doi: 10.1001/jamaneurol.2014.2886. Link to article on publisher's site
Korin, Netanel; Gounis, Matthew J.; Wakhloo, Ajay K.; and Ingber, Donald E., "Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics" (2015). Radiology Publications and Presentations. 117.