Endovascular treatment of tandem vascular occlusions in acute ischemic stroke
Department of Radiology, Division of Neuroimaging and Intervention; New England Center for Stroke Research; Department of Neurology
Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology | Surgery
BACKGROUND AND PURPOSE:
Tandem vascular occlusions are an important cause of acute ischemic stroke (AIS) and present unique treatment challenges. We report our experience of managing a subset of AIS patients with extracranial vascular stenting/angioplasty and intracranial revascularization.
METHODS: Consecutive patients who presented at three centers with AIS from tandem vascular occlusions confirmed by brain and neck CT imaging were included in the study. We retrospectively analyzed the patient demographics, National Institute of Health Stroke Scale (NIHSS) score and modified Rankin Scale (mRS) score at the time of admission, treatment strategy, angiographic results using the Thrombolysis In Cerebral Infarction (TICI) score, and clinical and imaging follow-up.
RESULTS: Twenty-eight patients were included. The mean NIHSS score at admission was 18. Extracranial carotid occlusions with a concomitant middle cerebral artery occlusion were seen in 89.3% of patients (n = 25) and vertebral artery combined with basilar artery lesions in 10.7% (n = 3). An antegrade approach (ie, treatment of the extracranial lesion first) was used in 24 patients (85.7%). Proximal occlusion recanalization was achieved usually with a stent (n = 27; 96.4%). Pursuant to intracranial revascularization techniques, greater than or equal to TICI 2A recanalization was seen in 96.4% of patients. An mRS score of less than or equal to 2 at 90 days was achieved in 56.5% of patients.
CONCLUSIONS: Our study shows preliminary data from three centers on recanalization of tandem occlusions in patients presenting with AIS. There was a preference to revascularize the proximal occlusion using a stent followed by distal recanalization with mechanical thrombectomy, intra-arterial thrombolysis or a combination of these. This approach has low periprocedural complications and can achieve an excellent angiographic and clinical outcome.
DOI of Published Version
J Neurointerv Surg. 2015 Mar;7(3):158-63. doi: 10.1136/neurintsurg-2013-011010. Link to article on publisher's site.
Journal of neurointerventional surgery
Puri, Ajit S.; Kuhn, Anna L.; Kwon, Hyon-Jo; Khan, Muhib; Hou, Samuel Y.; Lin, Eugene; Chueh, Juyu; van der Bom, Imramsjah M. J.; Dabus, Guilherme; Linfante, Italo; Gounis, Matthew J.; and Wakhloo, Ajay K., "Endovascular treatment of tandem vascular occlusions in acute ischemic stroke" (2015). Radiology Publications and Presentations. 112.